387343-81-9Relevant articles and documents
Copper(i)/Ganphos catalysis: enantioselective synthesis of diverse spirooxindoles using iminoesters and alkyl substituted methyleneindolinones
Cui, Hao,Duan, Zheng,Li, Er-Qing,Li, Ke,Mathey, Fran?ois,Song, Manman,Wang, Congcong,Wang, Yue,Wei, Donghui
supporting information, p. 3740 - 3746 (2020/06/03)
A copper-catalyzed asymmetric 1,3-dipolar cycloaddition of glycine iminoesters with alkyl substituted 3-methylene-2-oxindoles is described. By usingde novodesign of P-stereogenic phosphines as ligands, spiro[pyrrolidin-3,3'-oxindole]s are generated in good to excellent yields with high asymmetric induction. A further reduced catalyst loading of 0.1 mol% is sufficient to achieve a satisfactory enantioselectivity of 90% ee. The DFT calculations suggest the second Michael addition of the 1,3-dipole to be the rate- andenantio-determining step. A key feature of this 1,3-dipolar cycloaddition is the wide substrate applicability, even with alkyl aldehyde-derived azomethine ylide; thus it has streamlined a highly enantioselective access to a new class of antiproliferative agents, MDM2-p53.
Facile synthesis of pyrroloindoles: Via a rhodium(II)-catalyzed annulation of 3-benzylidene-indolin-2-ones and α-imino carbenes
Ma, Xueji,Xie, Xuemei,Liu, Li,Xia, Ran,Li, Tongyu,Wang, Hangxiang
supporting information, p. 1595 - 1598 (2018/02/14)
The annulation of 3-benzylidene-indolin-2-ones with α-imino rhodium carbenes generated in situ from N-sulfonyl-1,2,3-triazoles is presented. Through the appropriate choice of catalyst, the reactions can be reasonably modulated, and consequently, a number of pyrroloindole derivatives were constructed in moderate to excellent yields.
In?vitro targeting of colon cancer cells using spiropyrazoline oxindoles
Nunes, Rute C.,Ribeiro, Carlos J.A.,Monteiro, ?ngelo,Rodrigues, Cecília M.P.,Amaral, Joana D.,Santos, Maria M.M.
, p. 168 - 179 (2017/08/10)
We report on the synthesis and biological evaluation of a library of twenty-three spiropyrazoline oxindoles. The antiproliferative activity of the chemical library was evaluated in HCT-116 p53(+/+) human colon cancer cell line with eight deriva
