387358-27-2

Basic information

• Product Name: Ethanone, 1-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]-
• Synonyms: Ethanone, 1-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]-;1-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethanone;1-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethan-1-one
• CAS NO: 387358-27-2
• Molecular Formula: C₁₅H₂₂N₂O₃
• Molecular Weight: 278.34678
• Mol File: 387358-27-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 465.7°C at 760 mmHg
• Flash Point: 235.4°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 7.53E-09mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: Ethanone, 1-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]-(387358-27-2)
• EPA Substance Registry System: Ethanone, 1-[4-[4-(2-Methoxyethoxy)phenyl]-1-piperazinyl]-(387358-27-2)

Safety Data

• Hazardous Substances Data: 387358-27-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H22N2O3/c1-13(18)16-7-9-17(10-8-16)14-3-5-15(6-4-14)20-12-11-19-2/h3-6H,7-12H2,1-2H3

Upstream product

• 6482-24-2 2-Bromoethyl methyl ether 
• 67914-60-7 N-acetyl-N'-(4-hydroxyphenyl)piperazine 

Downstream Products

• 515160-72-2 1-(4-(2-methoxyethoxy)phenyl)piperazine 
• 377727-87-2 preladenant 

Relevant articles and documents

Fluorinated adenosine A2A receptor antagonists inspired by preladenant as potential cancer immunotherapeutics

Antagonism of the adenosine A2A receptor on T cells blocks the hypoxia-adenosinergic pathway to promote tumor rejection. Using an in vivo immunoassay based on the Concanavalin A mouse model, a series of A2A antagonists were studied and identified preladenant as a potent lead compound for development.Molecular modeling was employed to assist drug design and subsequent synthesis of analogs and those of tozadenant, including fluorinated polyethylene glycol PEGylated derivatives. The efficacy of the analogs was evaluated using two in vitro functional bioassays, and compound 29, a fluorinated triethylene glycol derivative of preladenant, was confirmed as a potential immunotherapeutic agent.