387825-03-8

Basic information

• Product Name: Salclobuzic acid
• Synonyms: Salclobuzic acid;Butanoic acid, 4-[(4-chloro-2-hydroxybenzoyl)aMino]-
• CAS NO: 387825-03-8
• Molecular Formula: C₁₁H₁₂ClNO₄
• Molecular Weight: 257.67028
• Mol File: 387825-03-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Salclobuzic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Salclobuzic acid(387825-03-8)
• EPA Substance Registry System: Salclobuzic acid(387825-03-8)

Safety Data

• Hazardous Substances Data: 387825-03-8(Hazardous Substances Data)

Usage

General Description

Salclobuzic acid, also known as salicylhydroxamic acid, is a chemical compound with the formula C8H7NO3. It is derived from salicylic acid and has been synthesized for its potential use as an antineoplastic and antituberculosis agent. Salclobuzic acid functions as a chelating agent, meaning it can bind to metal ions, and it has been studied for its ability to inhibit the growth of tumor cells. Additionally, it has been investigated for its potential to boost the efficacy of certain antibiotics in treating tuberculosis. However, further research is needed to fully understand the potential pharmacological properties and toxicity of salclobuzic acid before it can be applied in clinical settings.

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 5106-98-9 4-chlorosalicylic acid 
• 6937-16-2 ethyl γ-aminobutyrate hydrochloride 
• 530-62-1 1,1'-carbonyldiimidazole 
• 31544-40-8 7-chloro-benzo[e][1,3]oxazine-2,4-dione 

Relevant articles and documents

4-CNAB and preparation method thereof

The invention discloses 4-CNAB and a preparation method thereof, and belongs to the field of drug preparation. According to the technical scheme, the preparation method comprises the following steps:S1, adding dichloromethane into 4-chlorosalicylic acid, adding sodium bentonite and N, N-carbonyl diimidazole, then adding ethyl 4-aminobutyrate hydrochloride, dropwise adding triethylamine, adding adiluted hydrochloric acid solution, adjusting the pH value to 4.5-5, performing suction filtration, collecting filtrate, sequentially extracting with dilute ammonia water, pure water and a saturated sodium chloride solution, and concentrating an organic phase to obtain an intermediate I; S2, dissolving the intermediate I with a sodium hydroxide solution, dropwise adding a dilute hydrochloric acidsolution, adjusting the pH value to 4.5-5, separating out a product, and carrying out suction filtration and drying to obtain free acid; S3, dissolving free acid with isopropanol, adding a sodium hydroxide solution, after a reaction is carried out for 1 h, supplementing isopropanol and reacting for 1-2 h, performing suction filtration and drying to obtain 4-CNAB. The yield of each step is high, the product purity is good, and the salified product is easy for suction filtration.

Compounds and compositions for delivering active agents

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.