388109-44-2

Basic information

• Product Name: (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine
• Synonyms: (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine
• CAS NO: 388109-44-2
• Molecular Weight: 340.462
• Mol File: 388109-44-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine(388109-44-2)
• EPA Substance Registry System: (3S,4S)-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-1,1-dioxo-tetrahydro-thiophen-3-ylamine(388109-44-2)

Safety Data

• Hazardous Substances Data: 388109-44-2(Hazardous Substances Data)

Upstream product

• 275815-80-0 (S)-3-(4-fluorobenzyl)-piperidine 
• 78647-31-1 Methyl tetrahydro-4-oxo-3-thiophenecarboxylate 
• 388109-42-0 C₂₅H₃₁FN₂O₃S 
• 388114-49-6 [(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-[(3R,4S)-4-((R)-1-phenyl-ethylamino)-tetrahydrothiophen-3-yl]-methanone 
• 388114-54-3 C₁₃H₁₇NO₂S 
• 388109-43-1 [(3R,4S)-4-amino-1,1-dioxo-tetrahydrothiophen-3-yl]-[(S)-3-(4-fluorobenzyl)-piperidin-1-yl]-methanone 

Relevant articles and documents

CC chemokine receptor-3 (CCR3) antagonists: Improving the selectivity of DPC168 by reducing central ring lipophilicity

DPC168, a benzylpiperidine-substituted aryl urea CCR3 antagonist evaluated in clinical trials, was a relatively potent inhibitor of the 2D6 isoform of cytochrome P-450 (CYP2D6). Replacement of the cyclohexyl central ring with saturated heterocycles provid