3882-38-0Relevant articles and documents
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Gates et al.
, p. 1141 ()
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Synthesis and Evaluation of 3-Substituted 17-Methylmorphinan Analogs as Potential Anticonvulsant Agents
Newman, Amy Hauck,Bevan, Kathryn,Bowery, Norman,Tortella, Frank C.
, p. 4135 - 4142 (2007/10/02)
Dextromethorphan (1, (+)-3-methoxy-17-methylmorphinan) demonstrates anticonvulsant activity in a variety of in vitro and in vivo models of convulsive action.It is well known that 1 is metabolized to its phenolic derivative dextrorphan (2) and this metabolite is also a potent anticonvulsant.A series of (+)-3-substituted-17-methylmorphinans, which are structurally similar to 1 but are either not expected to be metabolized to 2 or might do so at a reduced rate, as compared to 1, were prepared.Three analogs, 5 ((+)-3-amino-17-methylmorphinan), 14 ((+)-3-ethoxy-17-methylmorphinan), and 15 ((+)-3-(2-propoxy)-17-methylmorphinan were found to possess potent anticonvulsant activity with full efficacy (ED50 25, 5.6, and 3.9 mg/kg, sc, respectively) in the rat supramaximal electroshock (MES) test.Binding potencies of these compounds to receptor sites labeled with 3H>dextromethorphan (3H>1), in rat brain and guinea pig brain subcellular fractions, and 3H>thienylcyclohexylpiperidine (TCP) and 3H>glycine in rat brain, were determined.Most of the analogs displaced 3H>1 from its binding sites, with compounds 14 (IC50 0.42 μM) and 15 (IC50 0.88 μM having equivalent potencies to 1 (IC50 0.59 μM), in rat brain, and no appreciable activity at the 3H>TCP or 3H>glycine-labeled sites.Compound 5 did not bind with appreciable activity to the 3H>1 site, in rat brain, but did bind to the 3H>TCP site with lower potency than the parent 1 (IC50 7.8 and 2.0 μM, respectively).The mechanism of anticonvulsant action of these agents is not clear although it appears that interaction at the 3H>1 sites may be involved.
MORPHINANS AND 6-KETOMORPHINANS UNSUBSTITUTED IN THE AROMATIC RING. HIGH ANALGESIC ACTIVITY OF (-)-6-KETO-N-METHYLMORPHINAN, IV.
Schmidhammer, Helmut,Jacobson, Arthur E.,Brossi, Arnold
, p. 391 - 394 (2007/10/02)
Elimination of the phenolic hydroxy group from (-)-4-hydroxy-6-keto-N-methylmorphinan (1) afforded the morphinan ketone 3 which was several times more potent as an analgesic than morphine.Removal of the carbonyl group in 3 by a Wolff-Kishner reduction gave the unsubstituted morphinan 7 which was only half as potent as morphine.