38847-75-5Relevant articles and documents
Carbon-Carbon Bond Formation by the Use of Chloroiodomethane as a C1 Unit. IV. The Mannich Reaction of Ketones by Means of Dihalomethane and Secondary Amine
Miyano, Sotaro,Mori, Akira,Hokari, Hiroshi,Ohta, Katsuaki,Hashimoto, Harukichi
, p. 1331 - 1332 (2007/10/02)
Treatment of ketones with dihalomethane (CH2Br2, CH2ClI, and CH2I2) in the presence of secondary amine, preferably pyrrolidine, gave the corresponding Mannich base in varing yields depending on the substrate and/or combination of the reagents.