38849-38-6

Basic information

• Product Name: Benzaldehyde, 2-bromo-4-methoxy-3-(phenylmethoxy)-
• CAS NO: 38849-38-6
• Molecular Formula: C15H13BrO3
• Molecular Weight: 321.17
• Mol File: 38849-38-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-bromo-4-methoxy-3-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-bromo-4-methoxy-3-(phenylmethoxy)-(38849-38-6)
• EPA Substance Registry System: Benzaldehyde, 2-bromo-4-methoxy-3-(phenylmethoxy)-(38849-38-6)

Safety Data

• Hazardous Substances Data: 38849-38-6(Hazardous Substances Data)

Upstream product

• 2973-58-2 2-bromoisovanillin 
• 100-44-7 benzyl chloride 
• 621-59-0 isovanillin 
• 100-39-0 benzyl bromide 

Downstream Products

• 135586-23-1 2,2′-diformyl-5,5′-dimethoxy-6,6′-bis(phenylmethoxy)biphenyl 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 135586-19-5 methyl 3-benzyloxy-2-bromo-4-methoxybenzoate 
• 135586-22-0 dimethyl 6,6'-dibenzyloxy-5,5'-dimethoxybiphenyl-2,2'-dicarboxylate 
• 135586-20-8 6'-Benzyloxy-5,5'-dimethoxy-6-methoxycarbonyloxy-3-methyl-biphenyl-2,2'-dicarboxylic acid dimethyl ester 

Relevant articles and documents

First total synthesis of the pavine alkaloid (±)-neocaryachine and its optical resolution

The first total synthesis of (±)-neocaryachine (1) was achieved using a radical cyclization to produce the dibenzo-9-azabicyclo[3.3.1]nonane pavine skeleton, following a Bischler-Napieralski reaction to construct an intermediate benzylisoquinoline. The resulting racemic mixture was separated by chiral column chromatography to provide pure (+)- and (?)-1.

Establishing Consensus Stereostructures for the Naphthoquinonopyrano-γ-lactone Natural Products (–)-Arizonin B1 and (–)-Arizonin C1 by Total Syntheses. Diastereocontrol of Oxa-Pictet–Spengler Cyclizations by Protective-Group Optimization

Previous total syntheses of arizonin C1 (4) led to opposite assignments of its absolute configuration. Here, we report the fourth total synthesis thereof. In addition, we disclose the first total synthesis of arizonin B1 (3) proceeding differently than via arizonin C1. The stereocenters of the two targets stemmed from an asymmetric dihydroxylation and an ensuing oxa-Pictet–Spengler cyclization. Their configurations were in line with Fernandes' assignments. Protective-group variation in the substrate modulated the diastereoselectivity of the Pictet–Spengler cyclization between 77:23 in favor of a trans disubstitution at C-3a vs. C-5 – used for preparing the natural (–)-arizonins C1 and B1 – and 100:0 in favor of a cis disubstitution – exploited for synthesizing the unnatural (+)-5-epi-arizonins C1 and B1. All naphthalenes of the present study were derived from the (benzyloxy)methoxynaphthalenediol 19. It resulted from a Diels–Alder reaction of the aryne 17a with the siloxyfuran 18a.

With anti-tumor activity of a biphenyl amide compound and its preparation method and application

The invention discloses a biphenyl amide compound with antitumor activity as well as a preparation method and application thereof. The structural formula of the compound is shown in the specification, wherein in the structural formula, R1 is hydrogen or halogen; R2 is alkoxy with carbon number of 1-4; the terminal of R2 is replaced by tert-amido; R2 is linked to the para-position of amide via an oxygen atom. The compound has good tumor cell inhibiting activity in vitro and can be used for preparing antitumor drugs, especially anti-hepatoma drugs and anti-breast cancer drugs. The preparation method of the biphenyl amide compound, provided by the invention, has the advantages that the raw materials are accessible, the reaction conditions are mild, the reaction process is simple to operate, and the used reagent is cheap.