388573-33-9Relevant articles and documents
Concise total syntheses of variolin B and deoxyvariolin B
Anderson, Regan J.,Hill, Jonathan B.,Morris, Jonathan C.
, p. 6204 - 6212 (2007/10/03)
The total synthesis of the marine alkaloid variolin B has been achieved in 8 steps and 17% overall yield, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. In addition, the deoxygenated analogue was prepared in 6 steps and 23% overall yield, starting from the same starting material.