388622-50-2Relevant articles and documents
Synthesis and photophysical properties of new fluorinated benzo[c]xanthene dyes as intracellular pH indicators
Liu, Jixiang,Diwu, Zhenjun,Leung, Wai-Yee
, p. 2903 - 2905 (2007/10/03)
Two new fluorinated benzo[c]xanthene dyes were synthesized by reaction of fluorinated 1,6-dihydroxynaphthalenes with 2,4- (and 2,5)-dicarboxy-3′-dimethylamino-2′-hydroxybenzophenone. The two critical fluorinated 1,6-dihydroxynaphthalene intermediates were prepared via a regioselective route. The fluorinated benzo[c]xanthene dyes exhibit desired lower pKa values (6.4 and 7.2, respectively) than their parent compound (pKa = 7.5) while the pH-dependent dual-emission characteristics are well retained. Their cell-permeable esters have been prepared for intracellular applications.