38869-05-5

Basic information

• Product Name: Piperazine, 1-(4-methoxyphenyl)-4-methyl-
• CAS NO: 38869-05-5
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• Mol File: 38869-05-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Piperazine, 1-(4-methoxyphenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-(4-methoxyphenyl)-4-methyl-(38869-05-5)
• EPA Substance Registry System: Piperazine, 1-(4-methoxyphenyl)-4-methyl-(38869-05-5)

Safety Data

• Hazardous Substances Data: 38869-05-5(Hazardous Substances Data)

Upstream product

• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 463-57-0 methanediol 
• 109-01-3 1-methyl-piperazine 
• 696-62-8 para-iodoanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 623-12-1 4-chloromethoxybenzene 
• 104-94-9 4-methoxy-aniline 
• 50-00-0 formaldehyd 
• 1448-52-8 N,N-bis(2-chloroethyl)-4-methoxybenzenamine 
• 74-89-5 methylamine 

Relevant articles and documents

A 1 - (substituted phenyl) -4 - methyl piperazine of the preparation process

The invention discloses a 1 - (substituted phenyl) - 4 - methyl piperazine of the preparation process, the process of the invention preparation method to 1 - (substituted phenyl) - piperazine compound A - 1 as a raw material, in the presence of acetic aci

The invention relates to a N, N - disubstituted hydrazide as ligand copper catalysis C - N coupling method (by machine translation)

The invention discloses a to N, N - disubstituted hydrazide as ligand copper catalysis C - N coupling method, the method uses the aromatic halides with amine compound as a raw material, in order to alcohol compound as the solvent, in order to copper or copper compound as a catalyst, in order to as formula I or formula II as shown by a N, N - disubstituted hydrazide as a ligand, the presence of a base, in the 10 - 130 °C generating C - N coupled reaction for generating N - aryl compound: the invention mild reaction conditions, high chemical selectivity, substrate and wide range of application, simplicity of operation, product is simple and easy to separation and environmental protection, the obtained product yield is higher. Wherein R1, R2 is selected from methyl, phenyl, 4 - methoxyphenyl, 4 - nitro-phenyl, 2 - methylphenyl, 2 - isopropyl phenyl; R3 is hydrogen or methoxy. (by machine translation)

Transition metal-free amination of aryl halides-A simple and reliable method for the efficient and high-yielding synthesis of N-arylated amines

A simple and reliable reaction protocol for the clean, fast, and high-yielding synthesis of various N-arylated amines derived from reactions of aryl halides with various (also sterically hindered) amines under transition metal-free reaction conditions is presented. Dioxane and KN(Si(CH3)3)2 were found to be the ideal solvent and base for this transformation. The conversion rates and yields observed are excellent and in the majority of the reactions performed significantly higher than that obtained in their catalyzed versions. Furthermore, the selective synthesis of 6-halopyridin-2-amines and asymmetric pyridine-2,6-diamines (derived from consecutive reactions of 2,6-dibromopyridine and 2,6-dichloropyridine, respectively, with different amines) is possible in almost quantitative yields (relative to 2,6-dihalopyridine) within very short reaction times. Purification of the 6-halopyridin-2-amine intermediates is not necessary, allowing the synthesis of pyridine-2,6-diamines in 'one-pot'. However, catalysts are in many cases not required to efficiently and selectively couple aryl halides with amines, making transition metal-free versions of the Buchwald-Hartwig reaction extremely attractive for the synthesis of N-arylated amines with substrates containing substituents on the aryl halide, which either promote regioselectivity and/or do not require regioselective aminations.