38869-96-4

Basic information

• Product Name: Carbamic acid, (tetrahydro-2-oxo-3-thienyl)-, phenylmethyl ester
• CAS NO: 38869-96-4
• Molecular Formula: C12H13NO3S
• Molecular Weight: 251.306
• Mol File: 38869-96-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (tetrahydro-2-oxo-3-thienyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (tetrahydro-2-oxo-3-thienyl)-, phenylmethyl ester(38869-96-4)
• EPA Substance Registry System: Carbamic acid, (tetrahydro-2-oxo-3-thienyl)-, phenylmethyl ester(38869-96-4)

Safety Data

• Hazardous Substances Data: 38869-96-4(Hazardous Substances Data)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 10593-85-8 DL-homocysteine thiolactone 
• 213487-91-3 Dimethyl (2RS,2'RS)-N,N'-bis(benzyloxycarbonyl)homocysteinate 

Downstream Products

• 167305-82-0 (S)-4-(acetylthio)-2-(benzyloxycarbonylamino)butanoic acid 
• 167305-41-1 (S)-2-((S)-4-Acetylsulfanyl-2-benzyloxycarbonylamino-butyrylamino)-6,6-dimethoxy-hexanoic acid methyl ester 
• 167305-85-3 (S)-2-((S)-4-Acetylsulfanyl-2-benzyloxycarbonylamino-butyrylamino)-6-hydroxy-hexanoic acid methyl ester 
• 167305-86-4 (S)-2-((S)-4-Acetylsulfanyl-2-benzyloxycarbonylamino-butyrylamino)-6-oxo-hexanoic acid methyl ester 
• 167305-87-5 (S)-2-((S)-2-Benzyloxycarbonylamino-4-mercapto-butyrylamino)-6-oxo-hexanoic acid methyl ester 
• 167305-43-3 (3S,7S,11S)-1-aza-3-benzyloxycarbonylamino-11-methoxycarbonyl-2-oxo-6-thiabicyclo[5.4.0]undecane 
• 106196-89-8 N,N'-Bis-(N-benzyloxycarbonyl-DL-homocysteinyl)-pentamethylendiamin 
• 103673-23-0 N,N'-Bis-(N-benzyloxycarbonyl-DL-homocysteinyl)-hexamethylendiamin 

Relevant articles and documents

Synthesis and in vitro enzyme activity of aza, oxa and thia derivatives of bacterial cell wall biosynthesis intermediates

Mechanism based inhibitors of diaminopimelate aminotransferase (DAP-AT) were designed using knowledge of its substrate specificity and mechanism. Synthesis of thiolester and amide substrate analogues was achieved prior to in vitro inhibition studies, but ester analogues proved too unstable to isolate. Thia substrate analogues showed no inhibitory properties, but the aza substrate analogue 12a showed reversible inhibition vs. DAP-AT and time dependent inhibition in the absence of the natural substrate 4. Substrate analogue 12a is thefirst example of an amide inhibitor of PLP dependent enzymes. Antibiotic properties of 12a were also briefly assessed.