389090-45-3

Basic information

• Product Name: Urea, N-[(1Z)-2-amino-1,2-dicyanoethenyl]-N'-(phenylmethyl)-
• CAS NO: 389090-45-3
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.252
• Mol File: 389090-45-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Urea, N-[(1Z)-2-amino-1,2-dicyanoethenyl]-N'-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-[(1Z)-2-amino-1,2-dicyanoethenyl]-N'-(phenylmethyl)-(389090-45-3)
• EPA Substance Registry System: Urea, N-[(1Z)-2-amino-1,2-dicyanoethenyl]-N'-(phenylmethyl)-(389090-45-3)

Safety Data

• Hazardous Substances Data: 389090-45-3(Hazardous Substances Data)

Upstream product

• 3173-56-6 benzyl isothiocyanate 
• 18514-52-8 2,3-diaminomaleonitrile 
• 193808-98-9 N-[(Z)-2-amino-1,2-dicyanovinyl]-N'-(4'-cyanophenyl)formamidine 
• 1187-42-4 diaminomaleonitrile 

Downstream Products

• 958602-02-3 9-benzyl-8-oxo-2-(pyridin-3-yl)-8,9-dihydro-7H-purine-6-carboxamide 
• 1265321-85-4 9-benzyl-2-(4-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carbonitrile 
• 1265321-82-1 9-benzyl-2-(4-cyanophenyl)-8-oxo-8,9-dihydro-7H-purine-6-carbonitrile 
• 1265321-79-6 9-benzyl-2-(4-methoxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carbonitrile 
• 1265321-74-1 9-benzyl-2-(4-methylphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carbonitrile 
• 389090-57-7 5-amino-1-benzyl-4-cyanoformimidoyl-imidazole-2-one 

Relevant articles and documents

HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS

Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

The reactions of diaminomaleonitrile with isocyanates and either aldehydes or ketones revisited

A reinvestigation of the reactions of urea derivatives of diaminomaleonitrile 2 with aldehydes or ketones in the presence of triethylamine has established that the products of these reactions are not pyrimidino[5,4-d]pyrimidines 9 as previously reported, but 8-oxo-6-carboxamido-1,2-dihydropurines 12, which are oxidized rapidly in air to the corresponding 6-carboxamidopurines 13. Similarly, the reaction of Schiff base derivatives of DAMN 5 with isocyanates in the presence of triethylamine gives the substituted 2-oxoimidazoles 20 and not the pyrimidine derivatives 8 as previously claimed. The compounds 20 cyclize in solution and are easily oxidized to 8-oxopurine-6-carbonitriles 22, which give the same 8-oxopurine-6-carboxamides 13 upon further hydrolysis.