38940-62-4

Basic information

• Product Name: 3-ACETYL-5-BROMOPYRIDINE
• Synonyms: 3-ACETYL-5-BROMOPYRIDINE;1-(5-BROMOPYRIDIN-3-YL)ETHANONE;Ethanone, 1-(5-bromo-3-pyridinyl)-;3-BROMO-5-ACETYLPYRIDINE;5-Acetyl-3-bromopyridine;1-(5-broMopyridin-3-yl)ethan-1-one;3-Acetyl-5-bromopyridine,97%;5-Bromo-3-acetylpyridine
• CAS NO: 38940-62-4
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.03
• EINECS: -0
• Product Categories: API intermediates;Pyridines;Heterocycle-Pyridine series
• Mol File: 38940-62-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 77-79°C
• Boiling Point: 279.321 °C at 760 mmHg
• Flash Point: 122.7 °C
• Appearance: powder
• Density: 1.534 g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 1.08±0.20(Predicted)
• BRN: 112808
• CAS DataBase Reference: 3-ACETYL-5-BROMOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ACETYL-5-BROMOPYRIDINE(38940-62-4)
• EPA Substance Registry System: 3-ACETYL-5-BROMOPYRIDINE(38940-62-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-36/37-36
• WGK Germany: 3
• Hazardous Substances Data: 38940-62-4(Hazardous Substances Data)

Usage

Description

3-Acetyl-5-bromopyridine is an organic compound characterized by its chemical structure, which features a pyridine ring with a bromine atom at the 5th position and an acetyl group at the 3rd position. It is a hoar or pale yellow solid, indicating its physical appearance.

Uses

Used in Pharmaceutical Industry:
3-Acetyl-5-bromopyridine is used as a key intermediate in the synthesis of benzimidazole CYP11B2 inhibitors. These inhibitors are potent and selective aldosterone blockers, which play a crucial role in treating diseases that result in the stiffening of the heart, such as heart failure and hypertension.

InChI:InChI=1/C7H6BrNO/c1-5(10)6-2-7(8)4-9-3-6/h2-4H,1H3

Upstream product

• 75-16-1 methylmagnesium bromide 
• 183608-47-1 N-methyl-N-methoxy-5-bromopyridine-3-carboxamide 
• 39620-02-5 5-bromonicotinoyl chloride 
• 20986-40-7 ethyl 5-bromo-3-pyridinecarboxylate 
• 105-53-3 diethyl malonate 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 
• 59-67-6 nicotinic acid 
• 141-78-6 ethyl acetate 

Downstream Products

• 205985-97-3 methyl (5-bromopyridin-3-yl)-3-oxopropanoate 
• 1426940-75-1 2-(4-fluorophenyl)-5-(5-(imidazo[1,2-a]pyridin-2-yl)pyridin-3-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide 
• 641615-42-1 N¹-(4-(5-bromopyridin-3-yl)pyrimidin-2-yl)-6-methylbenzene-1,3-diamine 
• 641615-41-0 4-(5-bromopyridin-3-yl)-N-(2-methyl-5-nitrophenyl)pyrimidin-2-amine 

Relevant articles and documents

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NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4? R5, R6, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using the compounds.

AMIDE DERIVATIVE AND MEDICINE

The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative represented by the following general formula [1]: (wherein R1 represents -CH2-R11, etc.; R2 represents alkyl, halogen, haloalkyl, etc.; R3 represents hydrogen, etc.; Het1 represents a group of the formula [6] as above, etc.; and Het2 represents pyrimidinyl, etc.), or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.