389621-78-7 Usage
Description
4-Aminomethyltetrahydropyran hydrochloride is an organic compound that serves as a crucial reagent in the synthesis of various pharmaceutical compounds. It is characterized by its ability to undergo core modification, which is essential in the development of specific inhibitors and other therapeutic agents.
Uses
Used in Pharmaceutical Industry:
4-Aminomethyltetrahydropyran hydrochloride is used as a reagent for core modification in the discovery of CC214-2, an orally available and selective inhibitor of mTOR kinase. This application is significant in the development of targeted therapies for various diseases, as mTOR kinase plays a crucial role in cell growth and proliferation.
Additionally, 4-Aminomethyltetrahydropyran hydrochloride is used as a reagent in the development of pyrazoloquinolines, which are PDE10A inhibitors. These inhibitors are being explored for their potential in treating schizophrenia, a severe mental disorder that affects millions of people worldwide.
Check Digit Verification of cas no
The CAS Registry Mumber 389621-78-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,9,6,2 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 389621-78:
(8*3)+(7*8)+(6*9)+(5*6)+(4*2)+(3*1)+(2*7)+(1*8)=197
197 % 10 = 7
So 389621-78-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO.ClH/c7-5-6-1-3-8-4-2-6;/h6H,1-5,7H2;1H
389621-78-7Relevant articles and documents
METHOD FOR PRODUCING NITRILE COMPOUND, CARBOXYLIC ACID COMPOUND OR CARBOXYLATE COMPOUND
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Page/Page column 16-17, (2010/11/08)
The present invention discloses a process for preparing a nitrile compound, a carboxylic acid compound or a carboxylic acid ester compound represented by the formula (2): wherein R represents a cyano group, a carboxyl group or an ester group, R1 and R2 each represent a group which does not participate in the reaction, which may have a substituent, and R1 and R2 may be combined to each other to form a ring, which comprises subjecting an acetic acid compound represented by the formula (1): wherein R, R1 and R2 have the same meanings as defined above, to decarboxylation in the presence of a metal catalyst.
