389621-79-8

Basic information

• Product Name: (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT
• Synonyms: 3-AMINO-5-NITROPHENYBORONIC ACID HCL SALT;(3-AMINO-5-NITROPHENYL)BORONIC ACID, HCL;(3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT;(3-AMINO-5-NITROPHENYL)BORONIC ACID HYDROCHLORIDE;(3-AMINO-5-NITROPHENYL)BORONIC ACID HYDROCHLORIDE SALT;3-AMINO-5-NITROBENZENEBORONIC ACID HYDROCHLORIDE;Boronic acid, (3-amino-5-nitrophenyl)-, monohydrochloride (9CI);3-Amino-5-nitrobenzeneboronic acid hydrochloride 97%
• CAS NO: 389621-79-8
• Molecular Formula: C₆H₇BN₂O₄*ClH
• Molecular Weight: 218.4
• Product Categories: BORONICACID;blocks;BoronicAcids;Boronic acids
• Mol File: 389621-79-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 136-141
• Boiling Point: 484.1 °C at 760 mmHg
• Flash Point: 246.6 °C
• Appearance: /
• Vapor Pressure: 3.48E-10mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT(CAS DataBase Reference)
• NIST Chemistry Reference: (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT(389621-79-8)
• EPA Substance Registry System: (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT(389621-79-8)

Safety Data

• Hazardous Substances Data: 389621-79-8(Hazardous Substances Data)

Usage

Description

(3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT is an organic compound that serves as a crucial reagent in the synthesis of heterocycle carboxamides. It is characterized by its unique chemical structure, which includes an amino group, a nitro group, and a boronic acid group. (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT plays a significant role in the development of pharmaceuticals, particularly in the treatment of immunological and oncological disorders.

Uses

Used in Pharmaceutical Industry:
(3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT is used as a key reagent for the preparation of heterocycle carboxamides. These carboxamides are essential in the development of Bruton's tyrosine kinase (Btk) inhibitors, which are vital for treating various immunological and oncological disorders. (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT's unique structure allows for the creation of effective inhibitors that can modulate the activity of Btk, a protein that plays a crucial role in the immune system and has been implicated in the development of certain cancers.
In the field of immunology, Btk inhibitors derived from (3-AMINO-5-NITROPHENYL)BORONIC ACID HCL SALT can be employed to target B cells, which are involved in the production of antibodies and the regulation of immune responses. By inhibiting Btk, these compounds can help regulate the immune system and provide relief from autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
In oncology, Btk inhibitors have shown promise in the treatment of certain types of cancer, particularly those that involve the overactivation of the Btk protein. By inhibiting Btk, these compounds can help prevent the uncontrolled growth and proliferation of cancer cells, offering a potential therapeutic approach for patients with various types of malignancies.

InChI:InChI=1/C6H7BN2O4.ClH/c8-5-1-4(7(10)11)2-6(3-5)9(12)13;/h1-3,10-11H,8H2;1H

Downstream Products

• 851667-18-0 3-benzenesulfonamido-5-nitrophenylboronic acid 
• 1240523-82-3 C₁₂H₁₁N₃O₂ 
• 1240523-83-4 5-(2-methylpyridin-4-yl)benzene-1,3-diamine