38988-02-2Relevant articles and documents
Characterization of oxalic acid derivatives as new metabolites of metamizol (dipyrone) in incubated hen's egg and human
Wessel, Julia C.,Matyja, Magdalena,Neugebauer, Michael,Kiefer, Heiko,Daldrup, Thomas,Tarbah, Fuad A.,Weber, Horst
, p. 15 - 25 (2006)
Metamizol (dipyrone, 1), a widely used drug with effective analgesic and antispasmodic properties, shows severe side effects like agranulocytosis and anaphylactic shock reactions, the reasons of which are not known until today. After oral administration 1
Ring Opening of 3(2H)-Pyrazolones by Oxidation with Periodate
Weber, Horst,Wollenberg, Eva
, p. 551 - 553 (2007/10/02)
In contrast to the aminopyrazolones 1 the pyrazolones 3 and 5 are stable against singlet oxygen.However, no difference is observed in reaction of the title compounds 1, 3 and 5 with sodium metaperiodate forming the oxidation products 2, 4 and 6, respectively.The (1)H- and (13)C-nmr-spectra of 4 as well as those of 2 are complex due to the existence of rotameric isomers at room temperature.