39062-72-1Relevant articles and documents
Synthesis and properties of nuclear hydroxylated derivatives of flufenamic acid and etofenamate
Boltze,Backer,Kreisfeld
, p. 183 - 186 (2007/10/02)
Synthesis of six nuclear hydroxylated derivatives of flufenamic acid and etofenamate (5-OH-, 4'-OH and 5,4'-(OH2) on a preparative scale is described. All compounds show low toxicity, by only weak anti-inflammatory activity in the rat paw kaolin edema test as compared to 2-(2-hydroxyethoxy)ethyl-N-(α,α,α-trifluoro-m-tolyl)-anthranilate (etofenamate, active substance of Rheumon Gel).