39075-25-7Relevant articles and documents
Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives
Zhang, Jian,Mu, Keman,Yang, Peng,Feng, Xinqian,Zhang, Di,Fan, Xiangyu,Wang, Qiantao,Mao, Shengjun
, (2021/08/03)
In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.
SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS
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Page/Page column 78, (2011/12/14)
The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds
ESTER LINKAGES BETWEEN LIGNIN AND GLUCURONIC ACID IN LIGNIN-CARBOHYDRATE COMPLEXES FROM FAGUS CRENATA
Imamura, Takeshi,Watanabe, Takashi,Kuwahara, Masaaki,Koshijima, Tetsuo
, p. 1165 - 1174 (2007/10/02)
Conjugate acid oxidation of benzyl esters with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and trifluoroacetic acid (TFA) was applied to the binding site analysis of ester linkages between lignin and glucuronoxylan in Fagus crenata wood.Based on the conjugate acid DDQ-oxidation of a watersoluble lignin-carbohydrate complex (LCC-WE) from the beech wood, the frequency of the ester bonds between the lignin and glucuronic acid residue of glucuronoxylan was determined to be 1.6 per molecule of LCC-WE. - Key words: Fagus crenata; Fagaceae; lignin-carbohydrate complex (LCC); 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).