39088-05-6

Basic information

• Product Name: 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide
• Synonyms: 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide;1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinecarboxamide;4,6-Dimethyl-2-hydroxypyridine-3-carboxamide
• CAS NO: 39088-05-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.1772
• EINECS: 254-285-3
• Mol File: 39088-05-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 469.6°C at 760 mmHg
• Flash Point: 237.8°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 5.42E-09mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide(39088-05-6)
• EPA Substance Registry System: 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide(39088-05-6)

Safety Data

• Hazardous Substances Data: 39088-05-6(Hazardous Substances Data)

Usage

General Description

1,2-dihydro-4,6-dimethyl-2-oxonicotinamide is a chemical compound with the molecular formula C8H11NO2. It is derived from nicotinamide, a form of vitamin B3, and has been studied for its potential pharmaceutical uses. The compound is a white crystalline solid and is soluble in water. 1,2-dihydro-4,6-dimethyl-2-oxonicotinamide has been investigated for its potential ability to act as an antioxidant and to protect against DNA damage caused by free radicals. It has also been studied for its potential as a therapeutic agent for various medical conditions, including neurodegenerative diseases and cancer.

InChI:InChI=1/C8H10N2O2/c1-4-3-5(2)10-8(12)6(4)7(9)11/h3H,1-2H3,(H2,9,11)(H,10,12)

Upstream product

• 1118-66-7 4-amino-3-penten-2-one 
• 108-13-4 malonodiamide 
• 64-17-5 ethanol 
• 109-89-7 diethylamine 
• 123-54-6 acetylacetone 
• 74-89-5 methylamine 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 24667-09-2 2-hydroxy-4,6-dimethylnicotinic acid 
• 16115-08-5 6-Hydroxy-2,4-lutidin 
• 143708-29-6 3-amino-4,6-dimethylpyridin-2(1H)-one 

Relevant articles and documents

The Kost-Sagitullin rearrangement in a series of 1-alkyl-2- (carbamoylmethyl)-4,6-dimethylpyrimidinium iodides

The rearrangement of 1-alkyl-2-(carbamoylmethyl)pyrimidinium iodides into substituted 2-alkylaminonicotinamides occurring in alcoholic solutions of amines has been studied. It was shown that in the presence of water the rearrangement of 2-(carbamoylmethyl)-1,4,6-trimethylpyrimidinium iodide is accompanied by the formation of a derivative of 2-oxo-1,2-dihydronicotinic acid, and under the action of ethylamine a rearrangement and transamination occurs leading to 2-ethylamino-4,6-dimethylnicotinamide.

Synthesis and Photophysical Properties of 3-Amino-4-arylpyridin-2(1 H)-ones

A method has been developed for the preparation of oxazolo-[5,4- b ]pyridin-2(1 H)-ones based on the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides. Hydrolysis of oxazolo[5,4- b ]pyridin-2(1 H)-ones and the Hoffmann reaction of 2-oxo-1,2-dihydropyridine-3-carboxamides yielded 3-aminopyridin-2(1 H)-ones, including 4-aryl substituted derivatives in the series, for which effective phosphors with a quantum yield of up to 0.78 were detected. Photophysical properties of 3-aminopyridin-2(1 H)-ones were studied by UV and luminescence spectroscopy methods, and the relationship between their structure and photophysical properties was revealed.