39093-44-2Relevant articles and documents
Preparation method of high-purity 2-benzylaniline
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Paragraph 0042-0044; 0045-0047; 0049-0053; 0054-0059, (2018/06/26)
The invention provides a preparation method of high-purity 2-benzylaniline and belongs to the field of medicine synthesis. The method includes the steps of performing a reflux reaction with hydrazinehydrate to prepare a hydrazone compound with 2-amino diphenyl ketone as an initial raw material in the presence of a high-boiling-point solvent and a drying agent; and in the presence of alkali, performing a denitriding reaction to the hydrazone compound. The method has simple operation and can reach more than 90% in yield of the 2-benzylaniline and more than 99.8% in product purity. The method issuitable for industrial large-scale production.