39099-13-3

Basic information

• Product Name: N-ETHYL-P-METHYLBENZYLAMINE
• Synonyms: N-ETHYL-P-METHYLBENZYLAMINE;N-(4-methylbenzyl)ethanamine;N-Ethyl-N-[2-(4-methylphenyl)ethyl]amine;N-(4-Methylbenzyl);N-[(4-methylphenyl)methyl]ethanamine
• CAS NO: 39099-13-3
• Molecular Formula: C₁₀H₁₅N
• Molecular Weight: 149.23
• Mol File: 39099-13-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 214.8±9.0 °C(Predicted)
• Appearance: /
• Density: 0.910±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.00±0.10(Predicted)
• CAS DataBase Reference: N-ETHYL-P-METHYLBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHYL-P-METHYLBENZYLAMINE(39099-13-3)
• EPA Substance Registry System: N-ETHYL-P-METHYLBENZYLAMINE(39099-13-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 39099-13-3(Hazardous Substances Data)

Usage

Description

N-ETHYL-P-METHYLBENZYLAMINE, also known as N-(4-Methylbenzyl)ethanamine, is an organic compound with the molecular formula C10H15N. It is a derivative of benzylamine, featuring an ethyl group and a methyl group attached to the benzene ring. N-ETHYL-P-METHYLBENZYLAMINE is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and properties.

Uses

Used in Pharmaceutical Industry:
N-ETHYL-P-METHYLBENZYLAMINE is used as a reagent for the preparation of novel piperidine-?4-?carboxamide derivatives. These derivatives are potential CCR5 inhibitors, which play a significant role in the treatment of various diseases, including HIV and certain cancers. N-ETHYL-P-METHYLBENZYLAMINE's ability to interact with the CCR5 receptor makes it a valuable asset in the development of new therapeutic agents.

Upstream product

• 80-40-0 ethyl ester of p-toluenesulfonic acid 
• 104-84-7 para-methylbenzylamine 
• 515-46-8 Ethyl benzenesulfonate 
• 20443-71-4 ethyl chlorobenzene-p-sulphonate 
• 15481-55-7 4-Nitrobenzenesulfonic acid ethyl ester 
• 26819-08-9 N-ethyl-4-methylbenzamide 
• 874-60-2 4-methyl-benzoyl chloride 
• 25079-96-3 N-(4-methylbenzyl)acetamide 

Downstream Products

• 457-63-6 ethyl-(4-fluoro-benzyl)-(4-methyl-benzyl)-amine 
• 429-80-1 ethyl-4-(fluoro-benzyl)-methyl-(4-methyl-benzyl)-ammonium; iodide 

Relevant articles and documents

Method for preparing amine compound by reducing amide compound

The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Pyrano-[2,3b]-pyridines as potassium channel antagonists

The design and synthesis of a series of highly functionalized pyrano-[2,3b]-pyridines is described. These compounds were assayed for their ability to block the IKur channel encoded by the gene hKV1.5 in patch-clamped L-929 cells. Six of the compounds in this series showed sub-micromolar activity, the most potent being 4-(4-ethyl-benzenesulfonylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3b]-pyridine-6-carboxylic acid ethyl-phenyl-amide with an IC50 of 378 nM.