391-53-7

Basic information

• Product Name: 2-FLUORO-9H-CARBAZOLE
• Synonyms: 2-FLUORO-9H-CARBAZOLE;2-Fluorocarbazole;9H-Carbazole, 2-fluoro-
• CAS NO: 391-53-7
• Molecular Formula: C₁₂H₈FN
• Molecular Weight: 185.1970232
• Mol File: 391-53-7.mol
• Article Data: 18

Chemical Properties

• Melting Point: 224.0 to 228.0 °C
• Boiling Point: 359.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.320±0.06 g/cm3(Predicted)
• PKA: 16.27±0.30(Predicted)
• CAS DataBase Reference: 2-FLUORO-9H-CARBAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-9H-CARBAZOLE(391-53-7)
• EPA Substance Registry System: 2-FLUORO-9H-CARBAZOLE(391-53-7)

Safety Data

• Hazardous Substances Data: 391-53-7(Hazardous Substances Data)

Usage

General Description

2-FLUORO-9H-CARBAZOLE is an organic compound with the molecular formula C13H9F. It is a derivative of carbazole, a tricyclic aromatic hydrocarbon. 2-FLUORO-9H-CARBAZOLE is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. 2-FLUORO-9H-CARBAZOLE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals, and it also has potential applications in materials science, such as in the development of organic semiconductors and optoelectronic devices. It is important to handle and use this chemical with care, as it may have harmful effects if exposed to the skin, eyes, or if inhaled or ingested.

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Relevant articles and documents

Preparation method of carbazole ring-containing compound

The invention provides a preparation method of a carbazole ring-containing compound, comprising the following step: a compound shown as a formula I-1 is subjected to a reaction in an organic solvent in the presence of metal and/or metal salt by using triphenylphosphine as a reducing agent to generate a compound shown as the formula I. In the invention, the carbazole ring compound is prepared by taking triphenylphosphine as a reducing agent and utilizing a nitro compound to react under the cooperation of the co-reducing agent, so that the dosage of triphenylphosphine is reduced, the generationamount of dangerous solid wastes is reduced, the post-treatment is easy, and the reaction temperature can be greatly reduced and the reaction time can be greatly shortened while high product yield isensured.

Nitrogen-Iodine Exchange of Diaryliodonium Salts: Access to Acridine and Carbazole

A nitrogen-iodine exchange protocol of diaryliodonium salts with sodium azide salt is developed for general construction of significant functional acridines and carbazoles, in which introduction of nitrogen at a late stage was successfully established avoiding heteroatom incompatibility. Inorganic sodium azide served as the sole nitrogen atom source in this transformation. The diversiform functional acridines and carbazoles were comprehensively achieved through annulated diaryliodonium salts, respectively. Notably, Acridine orange (a fluorescent indicator for cell lysosomal dye) and Carprofen (a nonsteroidal anti-inflammatory drug) were efficiently established through this protocol.

Preparation of 2 - substituted oxazole compounds

The present invention belongs to the field of organic chemistry, and particularly relates to a preparation method for 2-substituted carbazole compounds. According to the preparation method provided by the present invention, the raw material source is wide, reaction operation and post-treatment are simple and convenient, the yield is high, the application range is wide, and the industrial production is facilitated.