39149-13-8

Basic information

• Product Name: 4-acetaminophenoxyacetic acid
• Synonyms: 4-acetaminophenoxyacetic acid;(4-Acetamidophenoxy)acetic acid;2-(4-acetamidophenoxy)acetic acid;2-(4-acetamidophenoxy)ethanoic acid;2-(p-Acetamidophenoxy)acetic acid;Acetamidophenoxyacetic acid;Acetic acid, (4-(acetylamino)phenoxy)-;Acetic acid, (p-acetamidophenoxy)-
• CAS NO: 39149-13-8
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• Mol File: 39149-13-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 175-177 °C
• Boiling Point: 469.6 °C at 760 mmHg
• Flash Point: 237.8 °C
• Appearance: /
• Density: 1.326 g/cm³
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.18±0.10(Predicted)
• CAS DataBase Reference: 4-acetaminophenoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetaminophenoxyacetic acid(39149-13-8)
• EPA Substance Registry System: 4-acetaminophenoxyacetic acid(39149-13-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 39149-13-8(Hazardous Substances Data)

Usage

General Description

4-acetaminophenoxyacetic acid is a chemical compound that is a derivative of both acetaminophen and acetic acid. It is commonly used as an intermediate in the pharmaceutical industry for the synthesis of organic compounds. 4-acetaminophenoxyacetic acid has potential applications for the treatment of pain and inflammation, as it combines the analgesic properties of acetaminophen with the anti-inflammatory properties of acetic acid. It is also used in the production of drugs that target specific receptors in the central nervous system. Overall, 4-acetaminophenoxyacetic acid plays a crucial role in the development of various pharmaceutical products and is a key component in the synthesis of drugs for pain relief and inflammation.

InChI:InChI=1/C10H11NO4/c1-7(12)11-8-2-4-9(5-3-8)15-6-10(13)14/h2-5H,6H2,1H3,(H,11,12)(H,13,14)

Upstream product

• 1798-11-4 4-nitrophenoxyacetic acid 
• 2298-36-4 4-aminophenoxyacetic acid 
• 108-24-7 acetic anhydride 
• 103-90-2 4-acetaminophenol 
• 79-11-8 chloroacetic acid 
• 67202-81-7 ethyl 2-[4-(acetylamino)phenoxy]acetate 
• 75-36-5 acetyl chloride 

Downstream Products

• 2298-36-4 4-aminophenoxyacetic acid 
• 861797-43-5 (4-acetylamino-3-nitro-phenoxy)-acetic acid 
• 13730-70-6 (4-acetylamino-3,5-dinitro-phenoxy)-acetic acid 
• 29289-37-0 (4-acetylamino-phenoxy)-acetic acid p-phenetidide 
• 101284-10-0 (4-acetylamino-phenoxy)-acetic acid phenyl ester 
• 99072-52-3 (4-acetylamino-2-nitro-phenoxy)-acetic acid 
• 329-71-5 2,5-dinitrophenol 
• 42288-38-0 (3,5-dinitro-phenoxy)-acetic acid 
• 69447-81-0 (4-hydrazino-phenoxy)-acetic acid 
• 59820-55-2 2-(3-arnino-4-nitrophenoxy)acetic acid 
• 861613-09-4 (4-amino-3,5-dinitro-phenoxy)-acetic acid 
• 1616074-87-3 2-(4-acetamidophenoxy)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)acetamide 

Relevant articles and documents

PRMT5 INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

Boron trifluoride-methanol complex. Mild and powerful reagent for deprotection of acetylated amines. Scope and selectivity

A boron trifluoride-methanol complex demonstrated remarkable deprotection selectivity against commonly used amino-protecting groups in the deacetylation of acetanilides and high sensitivity to the steric hindrance of substrates. The scope and limitations of the reaction were explored.

PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF

Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5- mediated disorders are also described.