39151-19-4

Basic information

• Product Name: 3',5'-Dimethoxyacetophenone
• Synonyms: 1-(3,5-dimethoxyphenyl)-ethanon;1-(3,5-dimethoxyphenyl)ethanone;3’,5’-dimethoxy-acetophenon;LABOTEST-BB LT00233121;3',5'-DIMETHOXYACETOPHENONE;3,5-DIMETHOXYACETOPHENONE;1-(3,5-dimethoxyphenyl)ethan-1-one;3',5'-Dimethoxyacetophenone 3,5-Dimethoxyacetophenone
• CAS NO: 39151-19-4
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 254-322-3
• Product Categories: Terbutaline Bambuterol;C10;Carbonyl Compounds;Ketones
• Mol File: 39151-19-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 33-34 °C(lit.)
• Boiling Point: 290-291 °C(lit.)
• Flash Point: >230 °F
• Appearance: white to light yellow crystals or crystalline powder
• Density: 1.1272 (rough estimate)
• Refractive Index: n20/D 1.543(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• BRN: 2045586
• CAS DataBase Reference: 3',5'-Dimethoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-Dimethoxyacetophenone(39151-19-4)
• EPA Substance Registry System: 3',5'-Dimethoxyacetophenone(39151-19-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: KM5775717
• Hazardous Substances Data: 39151-19-4(Hazardous Substances Data)

Usage

Description

3',5'-Dimethoxyacetophenone is an organic compound characterized by its aromatic structure with two methoxy groups at the 3' and 5' positions and an acetophenone functional group. It is a versatile intermediate in the synthesis of various organic compounds and has potential applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
3',5'-Dimethoxyacetophenone is used as a starting reagent for the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic properties.
Used in Chemical Synthesis:
3',5'-Dimethoxyacetophenone is used as a starting reagent in the synthesis of 5,7-dimethoxy-3-methylindazole, a compound with potential applications in the development of new drugs and chemicals.
Used in Synthesis of Chiral Compounds:
3',5'-Dimethoxyacetophenone was used in the synthesis of (R)-(+)-1-(3,5-dimethoxyphenyl)ethyl acetate-ether-180, a chiral compound that may have applications in the pharmaceutical industry, particularly in the development of enantiomerically pure drugs.

Preparation

Obtained by reaction of acetyl chloride with 3,5-dimethoxybenzene.

Upstream product

• 186581-53-3 diazomethane 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 917-64-6 methyl magnesium iodide 
• 17213-58-0 3,5-dimethoxybenzamide 
• 506-82-1 dimethylcadmium 
• 14950-55-1 rac-1-(3,5-dimethoxyphenyl)ethan-1-ol 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 105-53-3 diethyl malonate 
• 917-54-4 methyllithium 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 40243-87-6 3,5-dimethoxystyrene 
• 7664-93-9 sulfuric acid 

Downstream Products

• 51863-60-6 3,5-dihydroxyacetophenone 
• 50841-50-4 (2-bromo-1-(3,5-dimethoxyphenyl)ethanone) 
• 51768-56-0 1,3-dimethoxy-5-ethylbenzene 
• 57860-52-3 [4-(3,5-Dimethoxy-phenyl)-pentyl]-dimethyl-amine 
• 54540-82-8 2-(3,5-Dimethoxyphenyl)-4-(4-fluorphenyl)-butan 
• 52763-25-4 2-(3,5-dimethoxyphenyl)-5-(4-fluorophenyl)-pentane 
• 57860-50-1 2-(3,5-dimethoxyphenyl)-5-phenylpentane 
• 54540-54-4 2-(3,5-Dimethoxyphenyl)-5-(4-Methylphenyl)Pentane 
• 54540-59-9 2(3,5-Dimethoxyphenyl)-6-(4-Fluorophenyl)Hexane 
• 83816-38-0 Lithium; 2-(3,5-dimethoxy-phenyl)-hexan-2-olate 
• 134804-55-0 2-benzyloxy-3',4,5',6-tetramethoxychalcone 
• 128113-91-7 (1S,1'S)-N-(1'-phenylethyl)-1-(3'',5''-dimethoxyphenyl)ethylamine 
• 128113-79-1 (1R,1'S)-N-(1'-phenylethyl)-1-(3'',5''-dimethoxyphenyl)ethylamine 
• 83816-37-9 Lithium; 2-(3,5-dimethoxy-phenyl)-butan-2-olate 

Relevant articles and documents

Iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabled aldehyde C-H methylation

A practical and general iron-catalyzed domino decarboxylation-oxidation of α,β-unsaturated carboxylic acids enabling aldehyde C-H methylation for the synthesis of methyl ketones has been developed. This mild, operationally simple method uses ambient air as the sole oxidant and tolerates sensitive functional groups for the late-stage functionalization of complex natural-product-derived and polyfunctionalized molecules.

Iron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Br?nsted Acid Catalysis

Alkylarylalkynes are converted with full regioselectivity into the corresponding arylketones by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (≤95 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes into acetyl derivatives via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by π-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system. (Figure presented.).

HETEROCYCLIC INHIBITORS OF MCT4

Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.