39183-17-0

Basic information

• Product Name: 4-Amino-2,3-dichlorphenol
• Synonyms: 4-Amino-2,3-dichlorphenol;4-AMino-2,3-dichlorophenol
• CAS NO: 39183-17-0
• Molecular Formula: C₆H₅Cl₂NO
• Molecular Weight: 178.02
• Mol File: 39183-17-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 301.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.560±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol
• PKA: 7.81±0.23(Predicted)
• CAS DataBase Reference: 4-Amino-2,3-dichlorphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2,3-dichlorphenol(39183-17-0)
• EPA Substance Registry System: 4-Amino-2,3-dichlorphenol(39183-17-0)

Safety Data

• Hazardous Substances Data: 39183-17-0(Hazardous Substances Data)

Usage

Description

4-Amino-2,3-dichlorophenol is an organic compound characterized by the presence of an amino group and two chlorine atoms on a phenol molecule. It is a key intermediate in the synthesis of various pharmaceutical compounds and exhibits significant chemical reactivity due to its functional groups.

Uses

Used in Pharmaceutical Industry:
4-Amino-2,3-dichlorophenol is used as a key intermediate in the synthesis of Fenhexamid and other pyrazine compounds for drug formulations. These compounds are particularly effective in treating inflammation, respiratory disorders, and viral infections, making them valuable in the development of new therapeutic agents.
In the synthesis of Fenhexamid, 4-Amino-2,3-dichlorophenol serves as a crucial building block, contributing to the compound's anti-inflammatory, anti-viral, and respiratory-aid properties. Its role in the development of these drugs highlights its importance in the pharmaceutical industry, as it enables the creation of medications that can alleviate a range of health issues.

Upstream product

• 111-48-8 2,2'-thiobis-ethanol 
• 576-24-9 2,3-dichlorophenol 
• 3209-22-1 1,2-Dichloro-3-nitrobenzene 
• 201656-71-5 2,3-dichloro-4-(2-phenyldiazen-1-yl)phenol 

Downstream Products

• 474662-55-0 2,3-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)aniline 
• 1352798-70-9 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)oxy)phenyl)urea 
• 1352798-80-1 1-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(2,3-dichloro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea 
• 1352798-56-1 ethyl (2-amino-4-(4-amino-2,3-dichlorophenoxy)pyridin-3-yl)carbamate 
• 1352798-46-9 C₁₅H₁₆Cl₂N₄O₃ 
• 1352798-45-8 7-(4-amino-2,3-dichlorophenoxy)-1-methyl-1H-imidazo[4,5-b]pyridin-2(3H)-one 
• 1352798-50-5 8-(4-amino-2,3-dichlorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one 
• 1352798-57-2 4-(4-amino-2,3-dichlorophenoxy)pyridine-2,3-diamine 
• 1352798-58-3 4-(4-amino-2,3-dichlorophenoxy)-3-nitropyridin-2-amine 
• 1562518-43-7 1-(2,3-dichloro-4-((2-chloropyrimidin-4-yl)oxy)phenyl)-3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)urea 
• 1562515-72-3 3-((4-(2,3-dichloro-4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)-phenoxy)pyrimidin-2-yl)amino)-5-ethynyl-N-(2-morpholinoethyl)benzamide 
• 1562515-80-3 3-((4-(2,3-dichloro-4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)-phenoxy)pyrimidin-2-yl)amino)-5-ethynylbenzamide 
• 1562515-84-7 3-((4-(2,3-dichloro-4-(3-(3-isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)-phenoxy)pyrimidin-2-yl)amino)-N-(2-(dimethylamino)ethyl)-5-ethynylbenzamide 
• 1562519-46-3 2,3-dichloro-4-((2-chloropyrimidin-4-yl)oxy)aniline 

Relevant articles and documents

Fenhexamid and analysis method thereof

The invention discloses fenhexamid and an analysis method thereof. The fenhexamid is prepared from aniline, hydrochloric acid, sodium nitrite solution, 2,3-dichlorophenol, sodium hydroxide, water, ethyl alcohol, sodium hydrosulfite, 1-methyl cyclohexanoic acid, methylene dichloride, N,N-dimethyl formamide, thionyl chloride, ethyl acetate and triethylamine. The fenhexamid content reaches 98% or above, and yield reaches 86-87%; in a fenhexamid analysis process, sodium hydrosulfite adopted for azo reduction for generating 2,3-dichloro-4-hydroxylaniline is high in reducibility and quick in weak alkaline reduction reaction, and the conversion rate reaches 98% or above by cross input of sodium hydroxide and sodium hydrosulfite; pH is kept in a range of 6-7 by acid reflux after adding of sodium hydrosulfite. Fenhexamid production conditions are mild, and easiness in operation, high safety, high total yield, low cost and suitableness for large-scale production and application to enterprises are realized.

Process for preparing 4-hydroxyanilines

The application describes a process for preparing 4-hydroxyanilines by the reaction of phenols with diazonium salts and subsequent reduction.

Cycloalkylcarboxanilides

This invention relates to cycloalkylcarboxanilides of the formula STR1 in which R represents halogen or halogenoalkyl, R1 represents halogen, alkyl or halogenoalkyl, n represents the numbers 0, 1, 2 or 3, X1, X2, X3 and X4 independently of one another represent hydrogen, halogen, alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylthio or halogenoalkylthio, and Z represents hydrogen, which have the utility as pesticides and fungicides.