39184-84-4Relevant articles and documents
Synthesis and biological evaluation of 3-biphenyl-4-yl-4-phenyl-4 h -1,2,4-triazoles as novel glycine transporter 1 inhibitors
Sugane, Takashi,Tobe, Takahiko,Hamaguchi, Wataru,Shimada, Itsuro,Maeno, Kyoichi,Miyata, Junji,Suzuki, Takeshi,Kimizuka, Tetsuya,Kohara, Atsuyuki,Morita, Takuma,Doihara, Hitoshi,Saita, Kyouko,Aota, Masaki,Furutani, Masako,Shimada, Yoshiaki,Hamada, Noritaka,Sakamoto, Shuichi,Tsukamoto, Shin-Ichi
supporting information; experimental part, p. 387 - 391 (2011/03/18)
We describe the preparation and evaluation of a novel series of glycine transporter 1 (GlyT1) inhibitors derived from a high-throughput screening hit. The SAR studies resulted in the discovery of 3-biphenyl-4-yl-4-(2-fluorophenyl)- 5-isopropyl-4H-1,2,4-tr
Oxidation during reductive cyclisations using Bu3SnH
Bowman, W. Russell,Heaney, Harry,Jordan, Benjamin M.
, p. 10119 - 10128 (2007/10/02)
Reductive cyclisations using Bu3SnH include an "oxidation" step if the removal of an acidic proton from the intermediate cyclised radical, by Bu3SnH acting as a base, is favourable. A "pseudo" SRN1 mechanism is proposed.