392-24-5

Basic information

• Product Name: 1,3-dichloro-5-fluoro-2-methoxybenzene
• Synonyms: 1,3-dichloro-5-fluoro-2-methoxybenzene
• CAS NO: 392-24-5
• Molecular Weight: 195.021
• Mol File: 392-24-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-dichloro-5-fluoro-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dichloro-5-fluoro-2-methoxybenzene(392-24-5)
• EPA Substance Registry System: 1,3-dichloro-5-fluoro-2-methoxybenzene(392-24-5)

Safety Data

• Hazardous Substances Data: 392-24-5(Hazardous Substances Data)

Upstream product

• 392-71-2 2,6-dichloro-4-fluorophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 697-91-6 2,6-dichloro-1,4-benzoquinone 

Relevant articles and documents

2-(2-ACRYLOYL-2,6-DIAZASPIRO[3.4]OCTAN-6-YL)-6-(1H-INDAZOL-4-YL)-BENZONITRILE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF G12C MUTANT KRAS PROTEIN FOR INHIBITING TUMOR METASTASIS

The present invention provides e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(lH-indazol-4-yl)-benzonitrile and e.g. 2-(2-acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-6-(1H-indazol-4-yl)- benzonitrile derivatives and related compounds of formula (I) as inhibitors of G12C mutant KRAS protein for treating tumor metastasis. The present description discloses exemplary compounds (e.g. pages 53 to 90; table 1; compounds I-1 to I-141), pharmacological data (e.g. page 125 to 128; table 2; example 1) and synthesis thereof (e.g. pages 129 to 143; examples 2 to 7). Exemplary compounds are e.g. 2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)-6-(5-methyl-1H-indazol-4-yl)-4- morpholinobenzonitrile (example 2; compound I-1) and 6-(2- acryloyl-2,7-diazaspiro[3.5]nonan-7-yl)-3-methoxy-2-(5-methyl-1H- indazol-4-yl)-4-morpholinobenzonitrile (example 7; compound I-84).

Formation of Nonaromatic Products in the Chlorination of Simple Substituted Aromatic Ethers

The neat chlorination of 4-chloroanisole produces 1,3,4,5,6-pentachloro-4-methoxycyclohexene in 35percent yield.Mono- and dichlorinated anisoles and a variety of simple substituted anisoles were chlorinated to determine the generality of nonaromatic product formation. 3,4-Dichloroanisole, 4-fluoroanisole, 4-bromoanisole, 4-methylanisole, and 4-chlorophenetole form similar products based on their spectral properties.These products are proposed to form by a cis-1,2-chlorine addition followed by rapid cis-1,4 chlorine addition.On the basis of the NMR data, a predominate configuration is proposed.