39224-65-2 Usage
Description
4,5-Dichloro-2-nitrophenol is an organic compound with the molecular formula C6H3Cl2NO3. It is characterized by the presence of two chlorine atoms at the 4th and 5th positions, and a nitro group at the 2nd position on a phenol ring. This chemical structure endows it with specific properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
4,5-Dichloro-2-nitrophenol is used as a key intermediate in the synthesis of dimethylpropanthioates, which are known as Cholesteryl Ester Transfer Protein (CETP) inhibitors. These inhibitors play a crucial role in modulating the transfer of cholesteryl esters between lipoproteins, thus potentially influencing the treatment of conditions related to lipid metabolism, such as atherosclerosis and hyperlipidemia.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4,5-dichloro-2-nitrophenol is utilized in the improved synthesis of hydroxyindoles. Hydroxyindoles are important building blocks for the creation of various pharmaceuticals, agrochemicals, and other specialty chemicals. The use of 4,5-dichloro-2-nitrophenol in this process enhances the efficiency and selectivity of the synthesis, leading to better yields and more cost-effective production of these valuable compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 39224-65-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,2,2 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 39224-65:
(7*3)+(6*9)+(5*2)+(4*2)+(3*4)+(2*6)+(1*5)=122
122 % 10 = 2
So 39224-65-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Cl2NO3/c7-3-1-5(9(11)12)6(10)2-4(3)8/h1-2,10H
39224-65-2Relevant articles and documents
The reaction of 1,2-dichloro-4,5-dinitrobenzene with hydroxide ion: Roles of meisenheimer complexes and radical pairs
Blasko?, Andrei,Bunton, Clifford A.,Gillitt, Nichollas D.,Bacaloglu, Radu,Yunes, Santiago F.,Zucco, Ce?sar
, p. 1146 - 1159 (2013)
The reaction of 1,2-dichloro-4,5-dinitrobenzene (DCDNB) with aqueous OH- produces (after acidification) 2-nitro-4,5-dichlorophenol with loss of NO 2. Nevertheless, with > 2 mol L-1 OH-, only DCDNB was recovered due to the
COVALENT INHIBITORS OF KRAS G12C
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Paragraph 0455, (2014/09/30)
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.
HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl
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Page/Page column 75; 76, (2008/06/13)
Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.
