39235-61-5

Basic information

• Product Name: 4'-benzyloxy-3'-(acetoxymethyl)bromoacetophenone
• Synonyms: 4'-benzyloxy-3'-(acetoxymethyl)bromoacetophenone
• CAS NO: 39235-61-5
• Molecular Weight: 377.235
• Mol File: 39235-61-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-benzyloxy-3'-(acetoxymethyl)bromoacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-benzyloxy-3'-(acetoxymethyl)bromoacetophenone(39235-61-5)
• EPA Substance Registry System: 4'-benzyloxy-3'-(acetoxymethyl)bromoacetophenone(39235-61-5)

Safety Data

• Hazardous Substances Data: 39235-61-5(Hazardous Substances Data)

Upstream product

• 39235-60-4 4'-benzyloxy-3'-acetoxymethylacetophenone 

Downstream Products

• 174607-68-2 (R)-1-[4-benzyloxy-3-hydroxymethylphenyl]-2-tert-butylaminoethanol 

Relevant articles and documents

Preparation method of leverbuterol and its salt

The invention provides a method for cheap and effective preparation of leverbuterol in industry. The method consists of: taking protected 4-hydroxy-3-hydroxymethyl acetophenone as the raw material to react with bromine to generate acyl or alkyl protected 4-hydroxy-3-hydroxymethyl bromoacetophenone, under in the presence of (1R, 2S)-(+)-indanol as a catalyst, using borane to conduct chiral reduction on carbonyl in the structural formula to obtain R configuration acyl or alkyl protected 4-hydroxy-3-hydroxymethyl alpha bromo phenethyl alcohol, then carrying out reaction with tert-butylamine to generate acyl or alkyl protected 4-hydroxy-3-hydroxymethyl phenylaminoethanol, and finally removing the acyl protecting group to obtain leverbuterol free alkali, and letting the free alkali and acid form a salt. The finished product has optical purity up to 99.9%, and no other chiral resolution way is needed for purification.