393078-37-0 Usage
Description
(2,3-Dichloro-6-Nitrophenyl)Methanol, also known as 2,3-Dichloro-6-nitrobenzyl Alcohol, is an organic compound with the chemical formula C7H5Cl2NO4. It is a colorless to pale yellow crystalline solid and is soluble in organic solvents. (2,3-Dichloro-6-Nitrophenyl)Methanol is characterized by the presence of two chlorine atoms at the 2nd and 3rd positions, a nitro group at the 6th position, and a hydroxyl group attached to the benzyl group. It is used as a reagent in the synthesis of various compounds, particularly in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(2,3-Dichloro-6-Nitrophenyl)Methanol is used as a reagent for the synthesis of androgen receptor modulators. These modulators are important in the treatment of various conditions related to androgen imbalance, such as prostate cancer, male pattern baldness, and osteoporosis.
Used in Synthesis of Anagrelide Impurity:
(2,3-Dichloro-6-Nitrophenyl)Methanol is also utilized in the synthesis of Anagrelide (A637300) impurity. Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity, which is used as an antithrombocythemic agent. It helps in the management of thrombocytosis, a condition characterized by an abnormally high number of platelets in the blood, which can lead to blood clots and other complications.
Check Digit Verification of cas no
The CAS Registry Mumber 393078-37-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,3,0,7 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 393078-37:
(8*3)+(7*9)+(6*3)+(5*0)+(4*7)+(3*8)+(2*3)+(1*7)=170
170 % 10 = 0
So 393078-37-0 is a valid CAS Registry Number.
393078-37-0Relevant articles and documents
Preparation method of anagrelide impurities B
-
, (2018/05/01)
The invention discloses a preparation method of anagrelide impurities B. The structure of the anagrelide impurities B is shown in formula I as shown in specification, and is obtained by nitratlon reaction, reduction reaction, halogenating reaction, conden
PROCESS FOR THE PREPARATION OF ETHYL-N-(2, 3-DICHLORO-6-NITROBENZYL) GLYCINE HYDROCHLORIDE
-
Page/Page column 12-13, (2008/12/08)
The invention relates to a process for the preparation of anagrelide, and for the preparation of intermediates for use in preparing anagrelide. The invention also relates to the inte?nediates per se, in particular compounds of formula (V) where R constitutes a suitable leaving group, which may not be hydrogen. The R group may be is selected from: (i) -SiR1 3, (ii) -CH2Ar, (iii) -COOR2, and (iv) sulfonates such as -SO2R3.
Method for the manufacture of anagrelide
-
, (2008/06/13)
Methods are provided for making Anagrelide base from 2,3-dichlorobenzaldehyde. A method is also provided for making an intermediate compound ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine from 2,3-dichlorobenzaldehyde and for reducing the glycine compound using either SnCl2 or a specially defined catalyst. A cyclization method to form Anagrelide base from the corresponding iminoquinazoline compound is further provided.
