393184-85-5

Basic information

• Product Name: Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester
• Synonyms: Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester
• CAS NO: 393184-85-5
• Molecular Weight: 813.386
• Mol File: 393184-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester(393184-85-5)
• EPA Substance Registry System: Toluene-4-sulfonic acid (S)-2-((S)-1-{(1R,3aS,7aR)-4-[2-[(S)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-ethyl)-5-methyl-5-triethylsilanyloxy-hexyl ester(393184-85-5)

Safety Data

• Hazardous Substances Data: 393184-85-5(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 308123-37-7 (1R,3aR,4S,7aR)-1-((1S,2S)-2-Hydroxymethyl-1,5-dimethyl-5-triethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol 
• 386743-52-8 Toluene-4-sulfonic acid (S)-2-[(S)-1-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyl-octahydro-inden-1-yl)-ethyl]-5-methyl-5-triethylsilanyloxy-hexyl ester 
• 100858-27-3 (S)-(Z)-{2-[5-(tert-butyldimethylsiloxy)-2-methylenecyclohexylidene]ethyl}diphenylphosphine oxide 
• 393184-88-8 Toluene-4-sulfonic acid (S)-5-methyl-2-[(S)-1-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-ethyl]-5-triethylsilanyloxy-hexyl ester 

Relevant articles and documents

A key intermediate for the convenient synthesis of series of vitamin D3 analogues with modified side chains

Tosylate 1, which features the vitamin D triene unit, was stereoselectively synthesized from commercially available starting materials. This key intermediate undergoes a very efficient one-pot, two-step reaction with tetrabutyl ammonium fluoride to afford vitamin D analogue 2, which bears a cyclic side chain. Reaction of 1 with lithium aluminium hydride and removal of the silyl protecting groups affords the 22-methylated vitamin D analogue 3.