393515-65-6

Basic information

• Product Name: 1-Piperazinecarboxamide, 4-(3-cyano-2-pyridinyl)-N-[4-(1-methylethyl)phenyl]-
• CAS NO: 393515-65-6
• Molecular Formula: C20H23N5O
• Molecular Weight: 349.436
• Mol File: 393515-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxamide, 4-(3-cyano-2-pyridinyl)-N-[4-(1-methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxamide, 4-(3-cyano-2-pyridinyl)-N-[4-(1-methylethyl)phenyl]-(393515-65-6)
• EPA Substance Registry System: 1-Piperazinecarboxamide, 4-(3-cyano-2-pyridinyl)-N-[4-(1-methylethyl)phenyl]-(393515-65-6)

Safety Data

• Hazardous Substances Data: 393515-65-6(Hazardous Substances Data)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 31027-31-3 4-isopropylphenylisocyanate 
• 84951-44-0 2-(piperazin-1-yl)nicotinonitrile 

Downstream Products

• 627512-47-4 4-(3-formyl-pyridin-2-yl)-piperazine-1-carboxylic acid (4-isopropyl-phenyl)-amide 

Relevant articles and documents

4-(2-Pyridyl)piperazine-1-carboxamides: Potent vanilloid receptor 1 antagonists

A series of 4-(2-pyridyl)piperazine-1-carboxamide analogues based on the lead compound 1 was synthesized and evaluated for VR1 antagonist activity in capsaicin-induced (CAP) and pH (5.5)-induced (pH) FLIPR assays in a rat VR1-expressing HEK293 cell line. Potent VR1 antagonists were identified through SAR studies. From these studies, 18 was found to be very potent in the in vitro assay [IC50=4.8 nM (pH) and 35 nM (CAP)] and orally available in rat (F%=15.1).