393524-67-9 Usage
Description
(2S,4R)-4-benzylpyrrolidine-2-carboxylic acid, also known as Boc-4-benzyl-L-proline, is a chiral chemical compound that belongs to the class of pyrrolidine carboxylic acids. It features two stereocenters and is widely recognized for its role as a building block in the synthesis of peptides and pharmaceuticals. This versatile intermediate exhibits various biological activities, such as antifungal and antibacterial properties, and has potential applications in materials science for the synthesis of polymeric materials.
Uses
Used in Pharmaceutical Synthesis:
(2S,4R)-4-benzylpyrrolidine-2-carboxylic acid is utilized as a key building block in the development of pharmaceuticals, owing to its ability to be incorporated into peptide and drug structures. Its chiral nature and unique structural features make it a valuable component in the creation of new drug candidates.
Used in Peptide Synthesis:
As a component of peptide synthesis, (2S,4R)-4-benzylpyrrolidine-2-carboxylic acid is used as an amino acid analog to create specific peptide sequences. Its incorporation can modulate the properties and functions of the resulting peptides, which is crucial for various biotechnological and medical applications.
Used in Materials Science:
In the field of materials science, (2S,4R)-4-benzylpyrrolidine-2-carboxylic acid is employed as a monomer in the synthesis of polymeric materials. Its structural attributes allow for the development of novel polymers with tailored properties for specific applications.
Used in Antimicrobial Applications:
(2S,4R)-4-benzylpyrrolidine-2-carboxylic acid is used as an antimicrobial agent for its antifungal and antibacterial properties. It can be incorporated into various products to prevent the growth of harmful microorganisms, contributing to the development of new treatments and preventive measures against infections.
Check Digit Verification of cas no
The CAS Registry Mumber 393524-67-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,3,5,2 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 393524-67:
(8*3)+(7*9)+(6*3)+(5*5)+(4*2)+(3*4)+(2*6)+(1*7)=169
169 % 10 = 9
So 393524-67-9 is a valid CAS Registry Number.
393524-67-9Relevant articles and documents
Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists
Ibrahim, Mohamed A.,Johnson, Henry W. B.,Jeong, Joon Won,Lewis, Gary L.,Shi, Xian,Noguchi, Robin T.,Williams, Matthew,Leahy, James W.,Nuss, John M.,Woolfrey, John,Banica, Monica,Bentzien, Frauke,Chou, Yu-Chien,Gibson, Anna,Heald, Nathan,Lamb, Peter,Mattheakis, Larry,Matthews, David,Shipway, Aaron,Wu, Xiang,Zhang, Wentao,Zhou, Sihong,Shankar, Geetha
, p. 1368 - 1381 (2012/04/04)
A series of subtype selective sphingosine 1-phosphate receptor 1 (S1P 1) antagonists are disclosed. Our high-throughput screening campaign revealed hit 1 for which an increase in potency and mouse oral exposure was achieved with minor modifications to the chemical scaffold. In vivo efficacy revealed that at high doses compounds 12 and 15 inhibited tumor growth. Further optimization of our lead series led to the discovery of proline derivatives 37 (XL541) and 38 which had similar efficacy as our first generation analogues at significantly lower doses. Analogue 37 displayed excellent pharmacokinetics and oral exposure in multiple species.
