393569-31-8 Usage
Description
SPLA2 INHIBITOR, also known as secretory phospholipase A2 inhibitor, is a class of compounds that specifically target and inhibit the activity of secretory phospholipase A2 enzymes. These enzymes play a crucial role in various physiological and pathological processes, including inflammation, cell proliferation, and cell death. By inhibiting the activity of sPLA2 enzymes, SPLA2 inhibitors can potentially modulate these processes and offer therapeutic benefits in various conditions.
Source:
SPLA2 inhibitors can be derived from natural sources, such as plants, or synthesized through chemical processes. The development of SPLA2 inhibitors has been an active area of research, with the aim of identifying novel compounds with improved potency, selectivity, and pharmacokinetic properties.
Production Methods:
The production of SPLA2 inhibitors can involve various methods, including extraction from natural sources, chemical synthesis, and biotechnological approaches. The choice of method depends on the specific inhibitor, its source, and the desired properties for therapeutic applications.
Uses
Used in Pharmaceutical Industry:
SPLA2 INHIBITOR is used as a therapeutic agent for the treatment of various inflammatory and immune-mediated diseases. The inhibition of sPLA2 enzymes can help reduce inflammation, modulate immune responses, and protect against tissue damage in conditions such as rheumatoid arthritis, asthma, and inflammatory bowel disease.
Used in Cardiovascular Applications:
SPLA2 INHIBITOR is used as a cardioprotective agent to prevent and treat cardiovascular diseases. The inhibition of sPLA2 enzymes can help reduce the risk of atherosclerosis, thrombosis, and ischemic events by modulating lipid metabolism, platelet activation, and vascular function.
Used in Neurological Applications:
SPLA2 INHIBITOR is used as a neuroprotective agent for the treatment of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The inhibition of sPLA2 enzymes can help reduce neuroinflammation, oxidative stress, and neuronal damage, thereby slowing down the progression of these diseases.
Used in Intestinal Reperfusion Injury:
SPLA2 INHIBITOR is used as a protective agent against intestinal reperfusion injury. Biological studies in rats have demonstrated that SPLA2 inhibitors can help protect the intestine from damage caused by ischemia and reperfusion, a common complication in surgeries involving the gastrointestinal tract.
Check Digit Verification of cas no
The CAS Registry Mumber 393569-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,3,5,6 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 393569-31:
(8*3)+(7*9)+(6*3)+(5*5)+(4*6)+(3*9)+(2*3)+(1*1)=188
188 % 10 = 8
So 393569-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C31H37NO4/c33-30(16-10-2-1-5-11-25-12-6-3-7-13-25)32-28(19-22-31(34)35)23-26-17-20-29(21-18-26)36-24-27-14-8-4-9-15-27/h3-4,6-9,12-15,17-18,20-21,28H,1-2,5,10-11,16,19,22-24H2,(H,32,33)(H,34,35)/t28-/m0/s1
393569-31-8Relevant articles and documents
Compounds and inhibitors of phospholipases
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, (2008/06/13)
The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids and their use in methods of therapy, including the treatment of inflammatory diseases, and to compositions and enantiomeric mixtures containing them.
