3936-54-7Relevant articles and documents
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00337; 00364, (2021/09/11)
The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
Promiscuous behavior of Rhizomucor miehei lipase in the synthesis of N-substituted β-amino esters
Monsalve, Leandro N.,Gillanders, Florencia,Baldessari, Alicia
experimental part, p. 1164 - 1170 (2012/04/10)
A mild and efficient procedure for the aza-Michael addition of amines to acrylates by using lipases as catalysts is reported. Various lipases, mono- and bifunctional amines, alkyl acrylates, and reaction parameters were studied. Under the optimal conditio
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold
Coumar, Mohane Selvaraj,Wu, Jian-Sung,Leou, Jiun-Shyang,Tan, Uan-Kang,Chang, Chung-Yu,Chang, Teng-Yuan,Lin, Wen-Hsing,Hsu, John T.-A.,Chao, Yu-Sheng,Wu, Su-Ying,Hsieh, Hsing-Pang
, p. 1623 - 1627 (2008/12/21)
Tricyclic 6,7-dihydro-4H-pyrazolo[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione was identified as a novel scaffold for Aurora kinase A inhibition through virtual screening. SAR exploration coupled with molecular modeling of 8a reveals the minimum pharmacophore requirements for Aurora kinase A inhibition.