3937-49-3

Basic information

• Product Name: 4α-Methylcyclohexane-1β-methanol
• Synonyms: 4α-Methylcyclohexane-1β-methanol;((1r,4r)-4-methylcyclohexyl)methanol;(trans-4-methylcyclohexyl)methanol;Trans-4-Methyl-1-Cyclohexanemethanol;Cyclohexanemethanol, 4-methyl-, trans-;(1α,4β)-1-Hydroxymethyl-4-methylcyclohexane;(1α,4β)-4-Methylcyclohexanemethanol;Trans-4-Methyl-1-Cyclohexanemethanol(WX640361)
• CAS NO: 3937-49-3
• Molecular Formula: C₈H₁₆O
• Molecular Weight: 128.21204
• Mol File: 3937-49-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 99-101 °C(Press: 23 Torr)
• Appearance: /
• Density: 0.884±0.06 g/cm3(Predicted)
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: 4α-Methylcyclohexane-1β-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4α-Methylcyclohexane-1β-methanol(3937-49-3)
• EPA Substance Registry System: 4α-Methylcyclohexane-1β-methanol(3937-49-3)

Safety Data

• Hazardous Substances Data: 3937-49-3(Hazardous Substances Data)

Usage

Description

4α-Methylcyclohexane-1β-methanol is a chemical compound with the molecular formula C8H16O. It is a colorless liquid characterized by a mild, minty odor. 4α-Methylcyclohexane-1β-methanol is derived from the bicyclic compound menthol and is recognized for its potential therapeutic effects, such as analgesic and anti-inflammatory properties. However, it is important to note that excessive exposure to 4α-Methylcyclohexane-1β-methanol can lead to irritation of the skin, eyes, and respiratory system.

Uses

Used in Flavor and Fragrance Industry:
4α-Methylcyclohexane-1β-methanol is utilized as a fragrance and flavoring agent in various consumer products due to its mild, minty scent. It adds a refreshing quality to products, making it a popular choice for items such as toothpaste, mouthwash, and chewing gum.
Used in Pharmaceutical Applications:
4α-Methylcyclohexane-1β-methanol has been studied for its potential therapeutic effects, which include analgesic and anti-inflammatory properties. This suggests that 4α-Methylcyclohexane-1β-methanol could be used in the development of medications aimed at relieving pain and reducing inflammation.
Used in Cosmetics and Personal Care Products:
Given its pleasant odor and potential therapeutic benefits, 4α-Methylcyclohexane-1β-methanol may also find use in the cosmetics and personal care industry, where it could be incorporated into products to provide a refreshing scent and possibly contribute to soothing skin or other applications.
It is important to consider the safety and regulatory guidelines when using 4α-Methylcyclohexane-1β-methanol in any of these applications to ensure that exposure levels are controlled and do not lead to adverse effects on health.

Upstream product

• 41692-50-6 trans-4-methyl-1-(ethoxycarbonyl)cyclohexane 
• 934-67-8 trans-4-methylcyclohexanecarboxylic acid 
• 39155-38-9 (4-methylcyclohex-3-en-1-yl)methanol 
• 55930-23-9 trans-4-methylcyclohexanecarbonyl chloride 
• 2808-80-2 4-methyl-1-methylidenecyclohexane 
• 99-94-5 p-Toluic acid 
• 589-91-3 p-methylcyclohexanol 
• 78-79-5 isoprene 
• 20292-15-3 4-methyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 
• 170811-08-2 trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate 
• 6493-79-4 methyl 4-methyl-3-cyclohexene-1-carboxylate 

Downstream Products

• 1666-77-9 trans-1-Chlormethyl-4-methyl-cyclohexan 
• 78507-26-3 trans-1-(bromomethyl)-4-methylcyclohexane 
• 7132-93-6 (trans-4-methyl-cyclohexyl)-acetic acid 
• 78507-27-4 trans-4-methylcyclohexylmethyl cyanide 
• 87002-25-3 [2-(4-Methyl-cyclohexyl)-ethyl]-benzene 
• 125533-10-0 2-(4-methylcyclohexyl)-1-phenylethan-1-one 
• 148258-68-8 (Z)-6-(trans-4-Methylcyclohexyl)-5-hexen-1-ol 

Relevant articles and documents

Rhodium(I)-Catalyzed Hydrogenation of Olefins. The Documentation of Hydroxyl-Directed Stereochemical Control in Cyclic and Acyclic Systems

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Immunomodulator

The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a formula I or a stereoisomer thereof in preparation of medicines for inhibiting IL-17A, and provides a new choice for clinically screening and/or preparing medicines for treating diseases related to IL-17A activity.

Hydrogenation of alkenes via cooperative hydrogen atom transfer

Radical hydrogenation via hydrogen atom transfer (HAT) to alkenes is an increasingly important transformation for the formation of thermodynamic alkane isomers. Current single-catalyst methods require stoichiometric oxidant in addition to hydride (H-) source to function. Here we report a new approach to radical hydrogenation: cooperative hydrogen atom transfer (cHAT), where each hydrogen atom donated to the alkene arrives from a different catalyst. Further, these hydrogen atom (H?) equivalents are generated from complementary hydrogen atom precursors, with each alkane requiring one hydride (H-) and one proton (H+) equivalent and no added oxidants. Preliminary mechanistic study supports this reaction manifold and shows the intersection of metal-catalyzed HAT and thiol radical trapping HAT catalytic cycles to be essential for effective catalysis. Together, this unique catalyst system allows us to reduce a variety of unactivated alkene substrates to their respective alkanes in high yields and diastereoselectivities and introduces a new approach to radical hydrogenation.