3946-08-5Relevant articles and documents
Valorization of Unconventional Lipids from Microalgae or Tall Oil via a Selective Dual Catalysis One-Pot Approach
Hess, Sandra K.,Schunck, Natalie S.,Goldbach, Verena,Ewe, Daniela,Kroth, Peter G.,Mecking, Stefan
supporting information, p. 13487 - 13491 (2017/10/05)
A dual catalysis approach enables selective functionalization of unconventional feedstocks composed of complex fatty acid mixtures with highly unsaturated portions like eicosapentaenoate (20:5) along with monounsaturated compounds. The degree of unsaturation is unified by selective heterogeneous hydrogenation on Pd/γ-Al2O3, complemented by effective activation to a homogeneous carbonylation catalyst [(dtbpx)PdH(L)]+ by addition of diprotonated diphosphine (dtbpxH2)(OTf)2. By this one-pot approach, neat 20:5 as a model substrate is hydrogenated to up to 80% to the monounsaturated analogue (20:1), this is functionalized to the desired C21 α,ω-diester building block with a linear selectivity of over 90%. This catalytic approach is demonstrated to be suitable for crude microalgae oil from Phaeodactylum tricornutum genetically engineered for this purpose, as well as tall oil, an abundant waste material. Both substrates were fully converted with an overall selectivity to the linear α,ω-diester of up to 75%.
Three new fatty acid esters from the mushroom Boletus pseudocalopus
Kim, Ki Hyun,Choi, Sang Un,Lee, Kang Ro
, p. 593 - 599 (2012/09/10)
A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC50 values in the range 2.77-12.51 μM. AOCS 2011.
A novel triacylglycerol from a cytotoxic extract of a red sea marine fungus
Nawwar,Hussein, Sahar A.,Hashim, Amani N.,Barakat, Heba H.,Mernitz, Gudrun,Cuypers, Beate,Linscheid, Michael,Lindequist, Ulrike
, p. 325 - 332 (2013/06/04)
INVESTIGATION of the CH2Cl2 extract of a taxonomically ....... unidentified anamorphic fungus strain MF 014, has yielded the glycerol triester, 1,3-O-bis-Z-11-eicosenoyl 2-O-Z-9, Z-12-nonadecadienoyl glycerol. The structure of this novel metabolite was established on the basis of extensive 1D- and 2D-NMR spectroscopic studies as well as on mass spectrometric analysis. The extract exhibited in vitro cytotoxic activity against human amniotic epithelial cells (FL cells) in the neutral red assay.
