39499-66-6

Basic information

• Product Name: 6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one
• Synonyms: 3(2H)-pyridazinone, 6-(3,4-dimethoxyphenyl)-4,5-dihydro-
• CAS NO: 39499-66-6
• Molecular Formula: C₁₂H₁₄N₂O₃
• Molecular Weight: 234.2512
• Mol File: 39499-66-6.mol
• Article Data: 10

Chemical Properties

• Density: 1.25g/cm³
• Refractive Index: 1.579
• CAS DataBase Reference: 6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one(39499-66-6)
• EPA Substance Registry System: 6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one(39499-66-6)

Safety Data

• Hazardous Substances Data: 39499-66-6(Hazardous Substances Data)

Usage

General Description

6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one is a chemical compound with a complex molecular structure. It belongs to the class of heterocyclic compounds and has a pyridazinone core with a dimethoxyphenyl substituent. 6-(3,4-dimethoxyphenyl)-4,5-dihydropyridazin-3(2H)-one has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and drug discovery. Additionally, it may also have industrial uses in the production of specialized chemicals or materials. The specific properties and potential uses of this compound would depend on further research and testing.

Upstream product

• 14563-40-7 methyl 4-(3,4-dimethoxyphenyl)-4-oxobutanoate 
• 5333-34-6 3-(3,4-dimethoxybenzoyl)propionic acid 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 183582-50-5 2-(4-Nitrobenzyl)-6-(3,4-dimethoxy-phenyl)-2,3,4,5-tetrahydropyridazin-3-one 
• 55901-95-6 6-(3,4-dimethoxyphenyl)-2,3-dihydropyridazin-3-one 

Relevant articles and documents

SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION

Disclosed are small molecules against cereblon to enhance effector T cell function. Methodos of making thes molecules and methods of using them to treat various disease states are also disclosed.

Iodine-mediated facile dehydrogenation of dihydropyridazin-3(2H)one

A new protocol for the dehydrogenation of dihydropyridazin-3(2H)-one has been carried out by catalytic amount of iodine in dimethyl sulphoxide in good yield with easy workup.

Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues

A number of 6-(3,4-dimethoxyphenyl)-4,5-dihydro-2H-pyridazin-3-ones and a novel series of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones were prepared and tested on the cGMP-inhibited phosphodiesterase (PDE3) and cAMP-specific phosphodiesterase (PDE4) enzymes. All tested compounds were found to specifically inhibit PDE4 except for pyridazinone 3b, which showed moderate PDE4 (pIC50 = 6.5) as well as PDE3 (pIC50 = 6.6) inhibitory activity. In both the pyridazinone and phthlazinone series it was found that N-substitution is beneficial for PDE4 inhibition, whereas in the pyridazinone series it also accounts for PDE4 selectivity. In the phthalazinone series, the cis-4a,5,6,7,8,8a-hexahydrophthalazinones and their corresponding 4a,5,8,8a-tetrahydro analogues showed potent PDE4 inhibitory potency (10/11c,d: pIC50 = 7.6-8.4). A molecular modeling study revealed that the cis-fused cyclohexa(e)ne rings occupy a region in space different from that occupied by the other fused (un)saturated hydrocarbon rings applied; we therefore assume that the steric interactions of these rings with the binding site play an important role in enzyme inhibition.