395099-48-6

Basic information

• Product Name: 3-(4-fluorophenyl)-1H-indazol-5-amine
• Synonyms: 3-(4-fluorophenyl)-1H-indazol-5-amine
• CAS NO: 395099-48-6
• Molecular Formula: C₁₃H₁₀FN₃
• Molecular Weight: 227
• Mol File: 395099-48-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 479.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.361±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.85±0.40(Predicted)
• CAS DataBase Reference: 3-(4-fluorophenyl)-1H-indazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-1H-indazol-5-amine(395099-48-6)
• EPA Substance Registry System: 3-(4-fluorophenyl)-1H-indazol-5-amine(395099-48-6)

Safety Data

• Hazardous Substances Data: 395099-48-6(Hazardous Substances Data)

Usage

General Description

3-(4-fluorophenyl)-1H-indazol-5-amine is a chemical compound with the molecular formula C14H10FN3. It is a derivative of indazole and contains a fluorophenyl group. 3-(4-fluorophenyl)-1H-indazol-5-amine is of interest to researchers due to its potential pharmacological properties, particularly in the development of new drugs. It is used as a building block in the synthesis of various organic compounds and has been studied for its potential therapeutic effects in the treatment of various diseases. Its structure and properties make it a valuable tool in the field of medicinal chemistry and drug discovery.

Upstream product

• 817200-27-4 C₁₃H₈FN₃O₂ 
• 478837-59-1 3-bromo-1H-indazol-5-amine 
• 1765-93-1 4-fluoroboronic acid 

Relevant articles and documents

Efficient synthesis of 3-aryl-1H-indazol-5-amine by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction under microwave-assisted conditions

Various 3-aryl-1H-indazol-5-amine derivatives were synthesized by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of (NH) free 3-bromo-indazol-5-amine with arylboronic acids under microwave-assisted conditions. The coupling reaction can be carried out under the conditions with dioxane/H2O as solvent, Pd(OAc)2 and RuPhos as catalyst system, and K3PO4 as a base in good to excellent yields.

Indazole compounds, compositions thereof and methods of treatment therewith

This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.