395101-69-6

Basic information

• Product Name: 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile
• Synonyms: 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile
• CAS NO: 395101-69-6
• Molecular Formula: C₁₃H₁₂BrN₃O
• Molecular Weight: 306.15788
• EINECS: -0
• Mol File: 395101-69-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile(395101-69-6)
• EPA Substance Registry System: 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile(395101-69-6)

Safety Data

• Hazardous Substances Data: 395101-69-6(Hazardous Substances Data)

Usage

General Description

3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile is a chemical compound with the molecular formula C15H15BrN2O. 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile is a nitrile derivative and is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It has a unique structure consisting of a bromine-substituted indazole ring attached to a tetrahydro-2H-pyran-2-yl group and a cyano group. The presence of the bromine atom and the nitrile functional group make it a versatile intermediate for the production of diverse chemical compounds. Its potential applications include drug discovery, medicinal chemistry, and the development of new materials.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 395101-67-4 3-bromo-1H-indazole-5-carbonitrile 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 395102-29-1 3-(3-Aminophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile 
• 395103-82-9 3-(3-hydroxyphenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile 
• 395102-14-4 3-((1E)-2-Phenylvinyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile 
• 395101-70-9 3-(4-Methoxyphenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile 
• 395101-84-5 3-Bromo-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carboxamide 
• 395102-44-0 3-(4-Chlorophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile 

Relevant articles and documents

Indazole compounds, compositions thereof and methods of treatment therewith

This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.