39512-49-7

Basic information

• Product Name: 4-(4-Chlorophenyl)piperidin-4-ol
• Synonyms: 4-(p-Chlorophenyl)-4-piperidinol;4-Hydroxy-4-(4-chlorophenyl)piperidine;4-Hydroxy-4-(p-chlorophenyl)piperidine;4-Piperidinol, 4-(4-chlorophenyl)-;4-(CHLOROPHENYL)-4-HYDROXYLPIPERIDINE;4-(CHLOROPHENYL)-4-HYDROXYPIPERIDINE;4-(P-CHLOROPHENYL)-4-HYDROXYPIPERIDINE;4-(4-CHLOROPHENYL)-4-PIPERIDINOL
• CAS NO: 39512-49-7
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.69
• EINECS: 254-479-8
• Product Categories: PHARMACEUTICAL INTERMEDIATES;BUILDING BLOCKS;Piperazine;Amines;Aromatics;Heterocycles;Miscellaneous Reagents
• Mol File: 39512-49-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 137-140 °C(lit.)
• Boiling Point: 344.5 °C at 760 mmHg
• Flash Point: 162.1 °C
• Appearance: White to creamy-white/Crystalline Powder
• Density: 1.1138 (rough estimate)
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Refrigerator
• Solubility: 340mg/l
• PKA: 13.92±0.20(Predicted)
• Water Solubility: 340 mg/L (20 ºC)
• BRN: 165923
• CAS DataBase Reference: 4-(4-Chlorophenyl)piperidin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chlorophenyl)piperidin-4-ol(39512-49-7)
• EPA Substance Registry System: 4-(4-Chlorophenyl)piperidin-4-ol(39512-49-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 39512-49-7(Hazardous Substances Data)

Usage

Description

4-(4-Chlorophenyl)piperidin-4-ol is an organic compound with a molecular structure that features a chlorophenyl group attached to a piperidine ring. 4-(4-Chlorophenyl)piperidin-4-ol has potential applications in various fields due to its unique chemical properties and interactions with biological systems.

Uses

Used in Pharmaceutical Research:
4-(4-Chlorophenyl)piperidin-4-ol is used as a potential fluorescent sigma receptor probe for [application reason] its ability to interact with sigma receptors, which are involved in various cellular processes and have been implicated in several diseases. 4-(4-Chlorophenyl)piperidin-4-ol can be utilized in the development of new drugs targeting these receptors, potentially leading to novel therapeutic approaches for conditions such as neurodegenerative diseases, pain management, and psychiatric disorders.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(4-Chlorophenyl)piperidin-4-ol can be used as a building block or intermediate for the synthesis of more complex molecules with specific biological activities. Its unique structure allows for further functionalization and modification, making it a valuable starting material for the development of new pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Analytical Chemistry:
4-(4-Chlorophenyl)piperidin-4-ol can also be employed as a reference compound or standard in analytical chemistry. Its distinct spectral properties and reactivity can be used to calibrate instruments, validate analytical methods, or establish reference values for the identification and quantification of similar compounds in various samples.

InChI:InChI=1/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2/p+1

Upstream product

• 91335-13-6 4-Brom-4-(4-chlor-phenyl)-piperidin 
• 235109-63-4 4-(4-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 26905-02-2 4-(4-chlorophenyl)piperidine 
• 106-39-8 bromochlorobenzene 
• 4783-65-7 N-benzyl-2-piperidinone 
• 56108-25-9 N-benzyl-4-(4-chlorophenyl)-4-hydroxypiperidin 

Downstream Products

• 52-86-8 haloperidol 
• 31293-71-7 VUF 5666 
• 26438-75-5 1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-4-(4-chloro-phenyl)-piperidin-4-ol 
• 90126-08-2 4-(4-Chloro-phenyl)-1-(2-pyridin-2-yl-ethyl)-piperidin-4-ol; compound with (Z)-but-2-enedioic acid 
• 91126-04-4 4-(p-Chlorphenyl)-1-cyanaminomethylen-4-hydroxypiperidin 
• 117992-75-3 2-{2-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-ethyl}-isoindole-1,3-dione 
• 110319-90-9 2-<<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl>methyl>-5-(4-fluorophenyl)pyrrole 
• 80775-82-2 4-<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl>-4-(4-methoxyphenyl)-1-phenyl-1-butanone 
• 129355-80-2 4-<4-(p-chlorophenyl)-4-hydroxypiperidino>-4'-(N-methylacetamido)butyrophenone 
• 43141-21-5 N-propargyl-4-(4'-chlorophenyl)-4-piperidinol 
• 140439-01-6 6-{6-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-hexyloxy}-2-phenyl-chromen-4-one 
• 1145-92-2 (1SR,2SR)-phenyl(2-phenylcyclopropyl)ketone 
• 42509-32-0 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1,3-diphenyl-butan-1-one 
• 41819-42-5 1,4-diphenyl-4-<4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl->1-butanone 

Relevant articles and documents

Preparation method of flupiperidinol

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method of flupiperidinol. The preparation method of the fluoropiperidinol, provided by the invention, comprises the following steps of providing 4-(4-chlorphenyl)-4-piperidinol of which the purity is 99% or above, providing 4-chloro-1-(4-fluorophenyl)butan-1-one of which the purity is more than 99%, mixing the 4-(4-chlorphenyl)-4-piperidinol, 4-chloro-1-(4-fluorophenyl)butan-1-one, an alkaline substance and a catalyst, and carrying out a first substitution reaction to obtain a crudeproduct, and mixing the crude product with an organic solvent, and sequentially carrying out reflux and crystallization to obtain the flupiperidinol. The flupiperidinol prepared according to the preparation method provided by the invention has relatively high yield and purity.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

METALLO-BETA-LACTAMASE INHIBITORS

The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.