39513-55-8

Basic information

• Product Name: 1,3-DiMethyl-2,4-dioxopyriMidine-5-carbohydrazide
• Synonyms: 1,3-DiMethyl-2,4-dioxopyriMidine-5-carbohydrazide;1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide;1,3-dimethyluracil-5-carbohydrazide
• CAS NO: 39513-55-8
• Molecular Formula: C7H10N4O3
• Molecular Weight: 198.1793
• Mol File: 39513-55-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.414±0.06 g/cm3(Predicted)
• PKA: 10.13±0.20(Predicted)
• CAS DataBase Reference: 1,3-DiMethyl-2,4-dioxopyriMidine-5-carbohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DiMethyl-2,4-dioxopyriMidine-5-carbohydrazide(39513-55-8)
• EPA Substance Registry System: 1,3-DiMethyl-2,4-dioxopyriMidine-5-carbohydrazide(39513-55-8)

Safety Data

• Hazardous Substances Data: 39513-55-8(Hazardous Substances Data)

Usage

Abbreviation

DMDPCH

Physical state

White crystalline solid

Usage

Precursor in the synthesis of pharmaceuticals, pesticides, and dyes

Potential applications

Treatment of various diseases (cancer, autoimmune disorders)

Role

Key intermediate in the production of several important chemical substances

Safety precautions

Handle with care, may be hazardous upon skin contact or ingestion

Upstream product

• 39513-47-8 5-ethoxycarbonyl-1,3-dimethyluracil 

Downstream Products

• 7251-53-8 ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Diversity of Intramolecular Rearrangements of Uracil Derivatives to Pyrazolones and Hydantoins Governed by a Prominent 5-Substituent Effect

Reaction of 1,3-dimethyluracil-5-carbohydrazides (4) with sodium ethoxide gave 4-ethoxycarbonyl-1,2-dihydro-3-pyrazolones (5) via a conventional intramolecular nucleophilic attack at the 6-position.In contrast, 1,3-disubstituted 5-(3-methylureido)uracil derivatives (6) were converted into the corresponding 3-methyl-5-ureidomethylenehydantoins (7) under analogous conditions.The latter rearrangement is unprecedented on account of the involvement of an initial nucleophilic attack at the 4-carbonyl carbon.The diversity of the intramolecular rearrangements of the uracil ring can be explained in terms of electronic nature of the substituent a t the 5-position.