39551-54-7

Basic information

• Product Name: 2,4-Dichloropyrido[3,2-d]pyrimidine
• Synonyms: 2,4-dichloropyrido[3,2-d]pyrimidine;4-dichloropyrido[3
• CAS NO: 39551-54-7
• Molecular Formula: C₇H₃Cl₂N₃
• Molecular Weight: 200.02
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 39551-54-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 168-169 ºC
• Boiling Point: 286.111 °C at 760 mmHg
• Flash Point: 154.152 °C
• Appearance: /
• Density: 1.573
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.31±0.30(Predicted)
• CAS DataBase Reference: 2,4-Dichloropyrido[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dichloropyrido[3,2-d]pyrimidine(39551-54-7)
• EPA Substance Registry System: 2,4-Dichloropyrido[3,2-d]pyrimidine(39551-54-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 39551-54-7(Hazardous Substances Data)

Usage

General Description

2,4-Dichloropyrido[3,2-d]pyrimidine is a chemical compound with the molecular formula C7H3Cl2N3. It is a heterocyclic compound that contains a pyrido[3,2-d]pyrimidine ring system with two chlorine atoms attached at the 2 and 4 positions. 2,4-Dichloropyrido[3,2-d]pyrimidine is primarily used in the pharmaceutical industry as a building block in the synthesis of various biologically active compounds and pharmaceutical drugs. Its unique structure and reactivity make it a valuable intermediate in the production of antiviral, antibacterial, and anticancer drugs. Additionally, 2,4-Dichloropyrido[3,2-d]pyrimidine has also been studied for its potential use as a herbicide and pesticide due to its inhibitory effect on certain enzymes and biological processes in plants and pests.

InChI:InChI=1/C7H3Cl2N3/c8-6-5-4(2-1-3-10-5)11-7(9)12-6/h1-3H

Upstream product

• 37538-68-4 pyrido<3,2-d>pyrimidine-2,4(1H,3H)-dione 
• 27507-08-0 3-(4-methoxybenzyl)pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 24195-07-1 pyridine-2,3-dicarboxylic acid 2-methyl ester 
• 656801-64-8 methyl 3-isocyanatopyridine-2-carboxylate 
• 50608-99-6 3-amino-pyridine-2-carboxylic acid amide 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 37538-68-4 pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 254-80-8 1,3,5-Triaza-naphthalin 
• 915302-21-5 2-chloropyrido[3,2-d]pyrimidine 
• 960156-26-7 2-chloro-4-phenylpyrido[3,2-d]pyrimidine 
• 915302-08-8 4-isopropylsulfanyl-2-phenylpyrido[3,2-d]pyrimidine 
• 915302-14-6 4-isopropylsulfanyl-2-(3-methoxyphenyl)pyrido[3,2-d]pyrimidine 

Relevant articles and documents

METHODS OF EXTENDING LIFESPAN BY ADMINISTERING FERROPTOSIS INHIBITORS

Provided herein is a method of extending the lifespan of an organism comprising administering to the organism an effective amount of a ferroptosis inhibitor. Also provided are compositions for extending lifespan comprising ferroptosis inhibitors.

ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT

The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group, R1 particularly being H or (C1-C6)alkyl group;A1 being an —NH— radical or —NH—CH2— radical;Cy1 particularly being a phenyl group,A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

Pyrimidine derivatives, preparation method therefor and application of pyrimidine derivatives

The invention belongs to the field of drug synthesis and relates to novel pyrimidine derivatives, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof, preparation methods of thenovel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof and use of the novel pyrimidine derivatives and the pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof in preparation of therapeutic agents, particularly PAK inhibitors. The derivatives disclosed by the invention are represented by a general formula (I) or (II), wherein each substituent is as defined in claims.