39577-43-0

Basic information

• Product Name: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine
• Synonyms: CCP;LABOTEST-BB LT00441048;1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE;1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine (CCP);piperazine hydrochloride/1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazine hydrochloride;1-(3-Chlorophenyl)-4-(3-chloro;1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HYDROCHLORIDE 97%;Piperazine, 1-(3-chlorophenyl)-4-(3-chloropropyl)-
• CAS NO: 39577-43-0
• Molecular Formula: C₁₃H₁₈Cl₂N₂
• Molecular Weight: 309.67
• EINECS: 254-529-9
• Product Categories: Piperazines;BUILDING BLOCKS;Piperaizine;Piperazine derivates;Nutritional fortification substances
• Mol File: 39577-43-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 199 °C
• Boiling Point: 395.8 °C at 760 mmHg
• Flash Point: 193.2 °C
• Appearance: /
• Density: 1.186
• Vapor Pressure: 1.79E-06mmHg at 25°C
• Refractive Index: 1.553
• PKA: 7.20±0.10(Predicted)
• Water Solubility: 140.1mg/L at 25℃
• CAS DataBase Reference: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(39577-43-0)
• EPA Substance Registry System: 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine(39577-43-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 24/25
• Hazardous Substances Data: 39577-43-0(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO BEIGE POWDER

Uses

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine is used in method of continuous flow process for preparation of Trazodone.Also, used in preparation of of Benzoaza-Alkylaryl Piperazine derivatives for treatment of mental diseases.

InChI:InChI=1/C13H18Cl2N2/c14-5-2-6-16-7-9-17(10-8-16)13-4-1-3-12(15)11-13/h1,3-4,11H,2,5-10H2

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 32229-98-4 1-(3-hydroxy-n-propyl)-4-(3-chlorophenyl)-piperazine 
• 13078-15-4 1-(3-chlorophenyl)piperazine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 112551-89-0 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-phenyl-piperazino)-propane 
• 6320-28-1 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-m-tolyl-piperazino)-propane 
• 114694-58-5 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-p-tolyl-piperazino)-propane 
• 114694-57-4 1-[4-(3-chloro-phenyl)-piperazino]-3-(4-o-tolyl-piperazino)-propane 
• 115098-03-8 1-[4-(3-chloro-phenyl)-piperazino]-3-[4-(4-chloro-phenyl)-piperazino]-propane 
• 6323-10-0 1-[4-(2-chloro-phenyl)-piperazino]-3-[4-(3-chloro-phenyl)-piperazino]-propane 
• 91532-01-3 3-<3-<4-(3-chlorophenyl)piperazin-1-yl>-propyl>-1,2,3-benzotriazin-4(3H)-one 
• 113642-20-9 4-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propoxy}-benzo[d][1,2,3]triazine 
• 91532-39-7 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-6-methyl-3H-benzo[d][1,2,3]triazin-4-one 
• 91532-38-6 7-Chloro-3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 
• 113675-73-3 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-6-nitro-3H-benzo[d][1,2,3]triazin-4-one 
• 113675-63-1 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3H-pyrido[3,4-d][1,2,4]triazin-4-one 
• 113642-28-7 3-{3-[4-(3-Chloro-phenyl)-piperazin-1-yl]-propyl}-3H-pyrido[3,2-d][1,2,3]triazin-4-one 
• 103076-63-7 2-(3-(4-(3-chlorophenyl)piperazino)propoxy)benzaldehyde 

Relevant articles and documents

Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides

As an extension of our previous work we describe the synthesis and pharmacological investigation of a new series of derivatives of pyrrole-3,4-dicarboximide possessing the 4-substituted-piperazin-1-ylalkyl group linked to the imide nitrogen. The products were evaluated for acute toxicity, and effectiveness in a series of CNS and arterial blood pressure tests. The preliminary pharmacological screening was determined in animal models. Several compounds demonstrated moderate to high analgesic activity in the 'writhing syndrome' test (5f-1/640 LD50). Some of the structure-activity relationships are also discussed.

Benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs

The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.