39616-95-0

Basic information

• Product Name: 4-Fluoro-2-nitrophenylacetic acid
• Synonyms: 4-Fluoro-2-nitrophenylacetic acid;4-Fluoro-2-nitro-benzeneacetic acid;2-(4-fluoro-2-nitrophenyl)acetic acid;BENZENEACETIC ACID, 4-FLUORO-2-NITRO-
• CAS NO: 39616-95-0
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.1359432
• Mol File: 39616-95-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 350.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.498±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 3.91±0.10(Predicted)
• CAS DataBase Reference: 4-Fluoro-2-nitrophenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-nitrophenylacetic acid(39616-95-0)
• EPA Substance Registry System: 4-Fluoro-2-nitrophenylacetic acid(39616-95-0)

Safety Data

• Hazardous Substances Data: 39616-95-0(Hazardous Substances Data)

Usage

General Description

4-Fluoro-2-nitrophenylacetic acid is a compound with the chemical formula C8H6FNO4. It is a derivative of phenylacetic acid, containing a fluorine atom at the 4th position and a nitro group at the 2nd position on the phenyl ring. This chemical is commonly used in organic synthesis and pharmaceutical research due to its potential biological and pharmacological properties. It has been studied for its potential as an anti-inflammatory and analgesic agent, as well as for its potential use in the synthesis of various drugs and pharmaceutical compounds. Additionally, its unique chemical structure and properties make it a valuable tool for understanding the molecular mechanisms of biological processes and drug interactions.

Upstream product

• 446-10-6 2-nitro-4-fluorotoluene 
• 95-92-1 oxalic acid diethyl ester 
• 147124-35-4 dimethyl 2-(4-fluoro-2-nitrophenyl)malonate 
• 364-74-9 1,4-difluoro-2-nitrobenzene 

Downstream Products

• 80733-63-7 (2-Amino-4-fluoro-phenyl)-acetic acid 
• 56341-39-0 6-fluoro-2-oxindole 
• 70931-83-8 <4-Fluoro-2-(4-nitrophenylthio)phenyl>acetic acid 

Relevant articles and documents

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported

FORMULATIONS FOR PHARMACEUTICAL AGENTS IONIZABLE AS FREE ACIDS OR FREE BASES

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HETEROCYCLICALLY SUBSTITUTED INDOLINONES, THEIR PRODUCTION AND USE AS MEDICAMENTS

The invention relates to heterocyclically substituted indolinones of general formula (I), in which R1 to R5 and X are defined as cited in claim 1, to their tautomers, diastereomers, enantiomers and to their mixtures, prodrugs and salts, in particular their physiologically compatible salts. Said compounds exhibit valuable pharmacological characteristics, in particular an inhibiting action on various receptor tyrosine kinases and cyclin-CDK complexes and on the proliferation of endothelial cells and various tumour cells. The invention also relates to medicaments containing said compounds, to the use of the latter and to a method for producing the same.