39631-30-6

Basic information

• Product Name: 2-(4-bromobenzoyl)hydrazinecarbothioamide
• Synonyms: 2-(4-bromobenzoyl)hydrazinecarbothioamide
• CAS NO: 39631-30-6
• Molecular Weight: 274.141
• Mol File: 39631-30-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-bromobenzoyl)hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromobenzoyl)hydrazinecarbothioamide(39631-30-6)
• EPA Substance Registry System: 2-(4-bromobenzoyl)hydrazinecarbothioamide(39631-30-6)

Safety Data

• Hazardous Substances Data: 39631-30-6(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 79-19-6 thiosemicarbazide 
• 586-75-4 4-chlorobenzoyl chloride 
• 333-20-0 potassium thioacyanate 
• 5933-32-4 4-bromobenzoic acid hydrazide 

Downstream Products

• 106014-02-2 2-(p-Bromobenzoyl)hydrazino-4-(p-tolyl)-thiazole hydrobromide 
• 1620200-78-3 diethyl (3-((5-(4-bromophenyl)-1H-1,2,4-triazol-3-yl)thio)propyl)phosphonate 
• 13178-12-6 5-(4-bromophenyl)-1,3,4-thiadiazol-2-amine 
• 39631-33-9 C₈H₆BrN₃S 
• 1383783-65-0 4-(2-{[5-(4-bromophenyl)-4H-1,2,4-triazol-3-yl]thio}ethoxy)benzaldehyde 
• 1276032-73-5 5-p-bromophenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-1,2,4-triazole 
• 1276032-83-7 5-p-bromophenyl-3-(β-D-glucopyranosylthio)-1,2,4-triazole 
• 106013-99-4 2-[5-(4-Bromo-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-1-(4-chloro-phenyl)-ethanone; hydrobromide 
• 106013-98-3 1-(4-Bromo-phenyl)-2-[5-(4-bromo-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethanone; hydrobromide 
• 106013-97-2 3-(p-Bromophenyl)-5-(p-methylphenacylthio)-s-triazole hydrobromide 
• 106014-00-0 2,6-Bis-(4-bromo-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 106014-01-1 2-(4-Bromo-phenyl)-6-(4-chloro-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 106020-12-6 2-(p-Bromophenyl)-5-(p-tolyl)thiazolo<3,2-b>-s-triazole 
• 106014-03-3 3-(p-Bromophenyl)-5-(p-tolyl)thiazolo<2,3-c>-s-triazole 

Relevant articles and documents

Design and development of 1,3,5-triazine-thiadiazole hybrids as potent adenosine A2A receptor (A2AR) antagonist for benefit in Parkinson's disease

Various studies showed adenosine A2A receptors (A2ARs) antagonists have profound therapeutic efficacy in Parkinsons Disease (PD) by improving dopamine transmission, thus being active in reversing motor deficits and extrapyramidal symptoms related to the disease. Therefore, in the presents study, we have showed the development of novel 1,3,5-triazine-thiadiazole derivative as potent A2ARs antagonist. In the radioligand binding assay, these molecules showed excellent binding affinity with A2AR compared to A1R, with significant selectivity. Results suggest, compound 7e as most potent antagonist of A2AR among the tested series. In docking analysis with A2AR protein model, compound 7e found to be deeply buried into the cavity of receptor lined via making numerous interatomic contacts with His264, Tyr271, His278, Glu169, Ala63, Val84, Ile274, Met270, Phe169. Collectively, our study demonstrated 1,3,5-triazine-thiadiazole hybrid as a highly effective scaffold for the design of new A2A antagonists.

Novel panaxadiol triazole derivatives induce apoptosis in HepG-2 cells through the mitochondrial pathway

In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 ± 0.54 μM, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.

Magnetically Recyclable Nano-Fe 2O 3-Catalyzed Chemoselective Synthesis and Antioxidant Activity of Diethyl (3-((5-Aryl-1 H-1,2,4-triazol-3-yl)thio)propyl) phosphonates

An efficient, green, and chemoselective S-alkylation of 5-aryl-1H-1,2,4-triazole-3-thiones with diethyl (3-bromopropyl)phosphonate in water, catalyzed by nano-Fe2O3 under ligand-and base-free conditions, is reported. Clean reaction, less expensive catalyst, excellent yields, and easy workup are the advantages of the present method. The catalyst can be easily collected by a magnet and recycled without significant loss in catalytic activity. The newly synthesized compounds were screened for their antioxidant property by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay. The majority of the compounds exhibited good antioxidant activity.