3967-22-4 Usage
General Description
L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-, 5-(1,1-dimethylethyl) 1-methyl ester, also known as Fmoc-His(Trt)-OH, is a chemical compound used in the synthesis of peptides and proteins. It is a derivative of the amino acid L-histidine, containing a protecting group (Fmoc) on the amino group and a trityl (Trt) protecting group on the side chain. L-Histidine, N-[N-[(phenylmethoxy)carbonyl]-L-a-glutamyl]-,
5-(1,1-dimethylethyl) 1-methyl ester is commonly used in solid-phase peptide synthesis as a building block for incorporating L-histidine into peptides and proteins. Its presence allows for the controlled addition of L-histidine residues to the growing peptide chain, enabling the creation of specific sequences and structures. Additionally, the tert-butyl (tBu) protecting group on the carboxylic acid group ensures that the compound remains stable during synthesis. Overall, Fmoc-His(Trt)-OH plays a crucial role in the production of bioactive peptides and proteins for various research and medical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 3967-22-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,6 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3967-22:
(6*3)+(5*9)+(4*6)+(3*7)+(2*2)+(1*2)=114
114 % 10 = 4
So 3967-22-4 is a valid CAS Registry Number.
3967-22-4Relevant articles and documents
SYNTHESIS OF A HEPTAPEPTIDE FORMING A MODIFIED ACTH 4-10 FRAGMENT
Krysin, E. P.,Karel'skii, V. N.,Rabinovich, A. K.,Borovkova, S. Yu.
, p. 706 - 709 (2007/10/02)
A scheme is given for the synthesis of a heptapeptide representing a modified ACTH 4-10 fragment on the basis of which it is possible to create a preparation that is an effective adaptogen of peptide nature.A proposed variant of the synthesis permits a peptide with an adequate degree of purity to be obtained comparatively simply on a large scale.The intermediate compunds and the final products were obtained with good yields and were distinguished by chromatographic homogeneity.The heptapeptide synthesized did not differ with respect to its physicochemical characteristics and biological action from the analogous compound obtained previously.Some physicochemical characteristics of the compound obtained (angles of optical rotation, chromatographic mobilities) are given.
