39696-48-5Relevant articles and documents
Synthesis and structure-activity relationship of C-3 substituted triazolylthiomethyl cephems
Singh,Fiakpui,Galpin,Stewart,Singh,Micetich
, p. 301 - 309 (2007/10/03)
A series of C-3 substituted triazolylthiomethyl cephems with an aminothiazolemethoxyiminoacetamido side chain at C-7 were synthesized and tested for antimicrobial activity against clinically-relevant isolates. The compound with 3-pyridyl at C-5 and methyl at N-4 of the triazole moiety exhibited good antibacterial activity against both Gram-positive and Gram-negative bacteria, with the exception of pseudomonas spp against which none of the derivatives exhibited favorable activity.
Recherches en serie triazepine XVI. Condensation des composes β-dicarbonyles avec les thiosemicarbazides
Hasnaoui, A.,Lavergne, J.-P.,Viallefont, Ph.
, p. 301 - 306 (2007/10/02)
Condensations of β-dicarbonyl compounds with thiosemicarbazide and 1- and 2-methylthiosemicarbazide give three types of heterocyclic compounds.Depending upon the reagents and experimental conditions, triazepinones, triazepines, 1,2,4-triazolines or pyrazoles are formed.Mechanisms explaining these cyclisations are proposed.