39708-01-5 Usage
Description
6-O-Ethylguanosine is a derivative of guanosine, a nucleoside that plays a crucial role in various biological processes. It has been studied for its potential as a covalent carcinogenic lesion in DNA, which could have significant implications in the field of cancer research and treatment.
Uses
Used in Cancer Research:
6-O-Ethylguanosine is used as a research tool for understanding the mechanisms of DNA damage and repair, particularly in the context of cancer development. Its role as a covalent carcinogenic lesion in DNA allows scientists to investigate the effects of such lesions on cellular processes and the potential for targeted therapies.
Used in Pharmaceutical Development:
6-O-Ethylguanosine is used as a starting point for the development of novel anticancer drugs. Its unique properties as a DNA lesion may lead to the creation of targeted therapies that can specifically address the challenges posed by cancer cells with such lesions, potentially improving treatment outcomes and reducing side effects.
Used in Drug Delivery Systems:
Similar to gallotannin, 6-O-Ethylguanosine may also benefit from advancements in drug delivery systems. By employing various organic and metallic nanoparticles as carriers, the delivery, bioavailability, and therapeutic outcomes of 6-O-Ethylguanosine-based treatments could be significantly improved, enhancing their potential in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 39708-01-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,7,0 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 39708-01:
(7*3)+(6*9)+(5*7)+(4*0)+(3*8)+(2*0)+(1*1)=135
135 % 10 = 5
So 39708-01-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N5O5/c1-2-21-10-6-9(15-12(13)16-10)17(4-14-6)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,18-20H,2-3H2,1H3,(H2,13,15,16)/t5-,7-,8-,11-/m1/s1
39708-01-5Relevant articles and documents
Mehta,Ludlum
, p. 4329,4331 (1976)
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
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Paragraph 0349; 0351, (2016/03/11)
Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.
Nucleic acid related compounds. 114. Synthesis of 2,6-(disubstituted)purine 2′,3′-dideoxynucleosides and selected cytotoxic, anti-hepatitis B, and adenosine deaminase substrate activities
Robins, Morris J.,Wilson, John S.,Madej, Danuta,Tyrrell, D. Lorne J.,Gati, Wendy P.,Lindmark,Wnuk, Stanislaw F.
, p. 1297 - 1306 (2007/10/03)
Selected 2,6-(disubstituted)purine 2′,3′-didehydro-2′,3′-dideoxynucleosides and 2′,3′-dideoxynucleosides were prepared and evaluated. Treatment of 5′-protected ribonucleosides with phenoxythiocarbonyl chloride and 4-(dimethylamino)pyridine, or under Schot
