3973-90-8

Basic information

• Product Name: Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime
• CAS NO: 3973-90-8
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol File: 3973-90-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime(3973-90-8)
• EPA Substance Registry System: Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime(3973-90-8)

Safety Data

• Hazardous Substances Data: 3973-90-8(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime is a chemical compound that is commonly used in the pharmaceutical industry and organic synthesis. It is an oxime derivative of acetophenone and contains a hydroxy and methyl group on the phenyl ring. Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime is known for its ability to act as a chelating agent, forming complexes with metal ions. It is also utilized as a ligand in coordination chemistry and can be used in the preparation of various organic compounds. Additionally, Ethanone, 1-(2-hydroxy-5-methylphenyl)-, oxime exhibits potential antioxidant properties, making it a valuable compound in the development of antioxidant therapies.

Upstream product

• 108-95-2 phenol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 106-44-5 p-cresol 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 79-24-3 Nitroethane 
• 1206606-64-5 C₁₃H₁₅NO₄ 

Downstream Products

• 5676-58-4 2,5-dimethyl-1,3-benzoxazole 
• 75633-01-1 3,5-dimethyl-1,2-benzisoxazole 2-oxide 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 201941-49-3 [Cu(S₂CN(CH₂C₆H₅)2)(OC₆H₃(CH₃)CCH₃(NOH))] 
• 6375-17-3 2-acetylamino-p-cresol 
• 6387-15-1 3-amino-2-hydroxy-5-methylbenzenesulfonic acid 
• 1285695-62-6 1-(2,4-dinitrophenyl)-4-(5-methyl-benzoxazol-2-yl)pyrazole 
• 1285695-58-0 1-phenyl-4-(5-methylbenzoxazol-2-yl)pyrazole 
• 76288-34-1 7-Methyl-4-phenyl-3a,10b-dihydro-4H-2,10-dioxa-10a-aza-cyclopenta[a]fluorene-1,3-dione 
• 76288-28-3 3-(4-methoxystyryl)-1,2-benzisoxazole 
• 76288-26-1 5-Methyl-3-((E)-styryl)-benzo[d]isoxazole 
• 53155-26-3 3,5-dimethyl-1,2-benzisoxazole 

Relevant articles and documents

Acid Catalyzed Direct-Amidation-Dehydrocyclization of 2-Hydroxy-acetophenones to Benzoxazoles by a One-Pot Sustainable Synthesis

A series of 2-methyl-benzoxazoles have been synthesized starting from 2-hydroxy-acetophenones via a one-pot three steps reaction. Hydroxylamonium salt has been used as amidation agent. The reaction occurs with different anions, but the best results is achieved with hydroxylamonium hydrchloride. Despite the number of consecutive stages, the reaction is highly selective. Mild reaction conditions and various solvents can be used, but trifluoroacetic acid is the preferred. Almost, complete recovery of the trifluoroacetic acid can be achieved by vacuum distillation. The role of trifluoroacetic acid, as well as, of the hydroxylamonium salt suggests a cooperative effect leading to high selective formation of 2-methyl-benzoxazoles. Graphical Abstract: One-pot TFA catalyzed synthesis of benzoxazoles starting from 2-hydroxyacetophenones. (Chemical Equation Presented).

Benzisoxazole 2-oxides as novel UV absorbers and photooxidation inhibitors

Compounds with strong absorptions in the ultraviolet (UV) region of the spectrum, particularly the UVA and UVB, have seen much interest as UV screeners or absorbers in a wide variety of commercial products. A series of benzisoxazole 2-oxides have been synthesized and characterized by UV-vis spectroscopy. A number of derivatives have been shown to posses moderate to strong molar absorption coefficients in the UVB range (ca. 300 nm), the strongest being those derived from benzophenones. Three other derivatives containing additional electron withdrawing groups showed strong molar absorption coefficients in the UVA (ca. 340 nm). Solvent effects on the parent derivatives show changes in the molar absorption coefficients with little changes in the λmax values. Preliminary studies of these compounds as potential additives to prevent photooxidation of polystyrene showed considerable inhibition of polymer degradation with the parent unsubstituted benzisoxazole 2-oxide compounds being the most effective. Copyright 2013 John Wiley & Sons, Ltd. A series of benzisoxazole 2-oxides have been shown to posses moderate to strong molar absorption coefficients in the UVB range (ca. 300 nm) and three others with strong absorptions on the UVA (ca. 340 nm). Solvent effects of the parent derivatives show changes in the molar absorption coefficients with little changes in the λmax values. Preliminary studies of these compounds as potential additives to prevent photooxidation of polystyrene showed considerable inhibition of polymer degradation. Copyright

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst

Efficient one-step method for the synthesis of amides directly from ketones and benzoxazoles from (2-hydroxyaryl) ketones by the reaction of acetohydroxamic acid using sulfuric acid as catalyst was described.